{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:05:25Z","timestamp":1785330325299,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The growing interest in plant\u2010based medicines has increased attention toward medicinal plants as therapeutic agents. This study evaluated the antidiabetic and anticholinesterase potentials of five\n                    <jats:italic>Sideritis<\/jats:italic>\n                    species through\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010amylase,\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010glucosidase, AChE, and BChE inhibition assays, followed by LC\u2013MS\/MS profiling of the most active extracts.\n                    <jats:italic>Sideritis montana<\/jats:italic>\n                    subsp.\n                    <jats:italic>montana<\/jats:italic>\n                    dichloromethane extract exhibited the strongest\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010amylase inhibition (82.38%\u00a0\u00b1\u00a00.09%), while no extract showed notable\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010glucosidase activity. Moderate AChE inhibition was observed in\n                    <jats:italic>Sideritis lanata (<\/jats:italic>\n                    18.78\u00a0\u00b1\u00a00.91%), whereas BChE inhibition was more pronounced in\n                    <jats:italic>Sideritis argyrea<\/jats:italic>\n                    (44.96%\u00a0\u00b1\u00a00.15%) and\n                    <jats:italic>S. lanata<\/jats:italic>\n                    (38.23%\u00a0\u00b1\u00a00.08%) dichloromethane extracts. LC\u2013MS\/MS analysis revealed chlorogenic acid, rosmarinic acid, and quinic acid as major constituents, especially abundant in butanol and water extracts of\n                    <jats:italic>Sideritis hololeuca<\/jats:italic>\n                    ,\n                    <jats:italic>S. lanata<\/jats:italic>\n                    , and\n                    <jats:italic>Sideritis libanotica<\/jats:italic>\n                    . Dichloromethane fractions were richer in mid\u2010polarity phenolics such as 4\u2010OH\u2010benzoic, syringic and vanillic acids. Overall, the results highlight species\u2010 and solvent\u2010dependent bioactivity, suggesting\n                    <jats:italic>Sideritis<\/jats:italic>\n                    taxa as promising sources of natural enzyme inhibitors.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71519","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T18:16:13Z","timestamp":1785089773000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional Evaluation of Five\n                    <i>Sideritis<\/i>\n                    Species Traditionally Consumed as Herbal Teas: Enzyme Inhibitory Activities Relevant to Neurodegenerative and Metabolic Disorders"],"prefix":"10.1002","volume":"23","author":[{"given":"Hilal","family":"\u00d6zbek","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Atat\u00fcrk University  Erzurum T\u00fcrkiye"},{"name":"Medicinal Aromatic Plant and Drug Research Center Atat\u00fcrk University  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif Beyza","family":"\u00d6zer","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Ondokuz May\u0131s University  Samsun T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6mer","family":"\u00c7e\u00e7en","sequence":"additional","affiliation":[{"name":"Department of Hydrobiology Faculty of Science Karamanoglu Mehmetbey University  Karaman T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0857-4776","authenticated-orcid":false,"given":"Hafize","family":"Yuca","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Atat\u00fcrk University  Erzurum T\u00fcrkiye"},{"name":"Medicinal Aromatic Plant and Drug Research Center Atat\u00fcrk University  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z\u00fchal","family":"G\u00fcvenalp","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Atat\u00fcrk University  Erzurum T\u00fcrkiye"},{"name":"Medicinal Aromatic Plant and Drug Research Center Atat\u00fcrk University  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song\u00fcl","family":"Karakaya","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany Faculty of Pharmacy Atat\u00fcrk University  Erzurum 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