{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:05:13Z","timestamp":1785330313452,"version":"3.55.0"},"reference-count":71,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The present study provides the first comprehensive phytochemical and biological investigation of\n                    <jats:italic>Fumana juniperina<\/jats:italic>\n                    , highlighting its potential as a previously unexplored source of bioactive flavonoids. Ten flavonoids were isolated and identified from the\n                    <jats:italic>n<\/jats:italic>\n                    \u2010butanol fraction, including the rare (2S)\u2010naringenin\u20108\u2010sulfonic acid, previously reported only in\n                    <jats:italic>Fumana montana<\/jats:italic>\n                    , thereby expanding the chemotaxonomic knowledge of the genus\n                    <jats:italic>Fumana<\/jats:italic>\n                    . The fraction exhibited remarkable antioxidant activity in 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl (DPPH\n                    <jats:bold>\n                      <jats:sup>\u0387<\/jats:sup>\n                    <\/jats:bold>\n                    ) (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 9.35 \u00b1 0.56\u00a0\u00b5g\/mL), 2,2\u2032\u2010azino\u2010bis(3\u2010ethylbenzothiazoline\u20106\u2010sulfonic acid) (ABTS\n                    <jats:bold>\n                      <jats:sup>\u0387+<\/jats:sup>\n                    <\/jats:bold>\n                    ) (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 4.32 \u00b1 0.36\u00a0\u00b5g\/mL), and cupric reducing antioxidant capacity (CUPRAC) (A\n                    <jats:sub>0<\/jats:sub>\n                    .\n                    <jats:sub>50<\/jats:sub>\n                    : 10.60 \u00b1 0.15\u00a0\u00b5g\/mL) assays, together with moderate acetylcholinesterase (AChE) inhibition (IC\n                    <jats:sub>50<\/jats:sub>\n                    :79.46\u00a0\u00b5g\/mL). Notably, molecular docking and PASS prediction identified quercetin\u20103\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010\u03b2\u2010D\u2010glucoside and myricetin\u20103\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010\u03b2\u2010D\u2010glucoside as promising AChE inhibitors, displaying predicted binding affinities comparable to galantamine (\u22129.8\u00a0kcal\/mol). These findings support the growing interest in polyhydroxylated flavonoids as multifunctional natural scaffolds with potential relevance to oxidative stress and cholinergic dysfunction associated with neurodegenerative disorders. ADMET predictions further supported these findings, indicating favorable binding profiles and acceptable safety for selected flavonoids, while also identifying pharmacokinetic limitations of glycosylated derivatives. Together, these results establish\n                    <jats:italic>F. juniperina<\/jats:italic>\n                    as a valuable source of multifunctional flavonoids and provide a solid foundation for future structural optimization strategies targeting oxidative stress and cholinesterase\u2010mediated neurodegenerative disorders.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71520","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T18:07:45Z","timestamp":1785089265000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Flavonoids From\n                    <i>Fumana juniperina<\/i>\n                    (Lag. ex Dunal) Aerial Parts: Chemical Characterization, Antioxidant, and Anticholinesterase Activities Supported by In Silico Analysis"],"prefix":"10.1002","volume":"23","author":[{"given":"Abbes","family":"Benmerache","sequence":"first","affiliation":[{"name":"D\u00e9partement de Chimie, Laboratoire d'Obtention des Substances Th\u00e9rapeutiques (LOST) Universit\u00e9 Constantine 1\u2010fr\u00e8res Mentouri  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farida","family":"Larit","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Chimie, Laboratoire d'Obtention des Substances Th\u00e9rapeutiques (LOST) Universit\u00e9 Constantine 1\u2010fr\u00e8res Mentouri  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahia","family":"Kabouche","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Chimie, Laboratoire d'Obtention des Substances Th\u00e9rapeutiques (LOST) Universit\u00e9 Constantine 1\u2010fr\u00e8res Mentouri  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djemaa","family":"Berrehal","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Chimie, Laboratoire d'Obtention des Substances Th\u00e9rapeutiques (LOST) Universit\u00e9 Constantine 1\u2010fr\u00e8res Mentouri  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulmagid","family":"AlabdulMagid","sequence":"additional","affiliation":[{"name":"Equipe Chimie des Substances Naturelles, Campus Sciences Institut de Chimie Mol\u00e9culaire De Reims (ICMR)  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Voutquenne\u2010Nazabadioko","sequence":"additional","affiliation":[{"name":"Equipe Chimie des Substances Naturelles, Campus Sciences Institut de Chimie Mol\u00e9culaire De Reims (ICMR)  Reims 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