{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:09:06Z","timestamp":1788858546690,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Caseous lymphadenitis is a chronic infectious disease caused by\n                    <jats:italic>Corynebacterium pseudotuberculosis<\/jats:italic>\n                    that affects small ruminants, resulting in significant economic losses. In response, essential oils (EO) have emerged as promising natural alternatives for disease control. The present study evaluated the chemical composition, antioxidant capacity, and antibacterial activity of EO from\n                    <jats:italic>Origanum vulgare<\/jats:italic>\n                    (OVEO) and\n                    <jats:italic>Eucalyptus staigeriana<\/jats:italic>\n                    (ESEO) against\n                    <jats:italic>C. pseudotuberculosis<\/jats:italic>\n                    isolated from Northeastern Brazil. The antibacterial effect was assessed by disk diffusion, minimum inhibitory concentration (MIC), Minimum Bactericidal Concentration, time\u2013kill assays, and combination tests with cloxacillin. Gas chromatography analysis identified carvacrol as the major compound in OVEO, and D\u2010limonene in ESEO. OVEO demonstrated strong antibacterial efficacy, exhibiting inhibition zones of up to 74\u00a0mm and MICs ranging from 31.2 to 250\u00a0\u00b5g\/mL. Both EOs demonstrated bactericidal properties and exhibited additive interactions with cloxacillin (FICi 0.56\u20131.03). Furthermore, OVEO exhibited strong antioxidant activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a06.89\u00a0\u00b1\u00a00.58\u00a0\u00b5g\/mL). These findings underscore the significance of bioactive compounds with antibacterial potential, although further studies are necessary to evaluate their applicability for managing caseous lymphadenitis.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71523","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T06:36:30Z","timestamp":1785479790000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antibacterial Properties of\n                    <i>Origanum vulgare<\/i>\n                    and\n                    <i>Eucalyptus staigeriana<\/i>\n                    Essential Oils Single or in Combination With Cloxacillin Against\n                    <i>Corynebacterium pseudotuberculosis<\/i>"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6601-7038","authenticated-orcid":false,"given":"Wanderl\u00e9ia","family":"de Aguiar Policarpo","sequence":"first","affiliation":[{"name":"Cear\u00e1 State University, Post\u2010Graduate Program in Veterinary Sciences (PPGCV) Fortaleza Cear\u00e1 Brazil"},{"name":"Center For Bioprospecting and Applied Molecular Experimentation (NUBEM) Center on Health Science at INTA University Center \u2013 UNINTA Sobral Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Jos\u00e9 Negreiros","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Center For Bioprospecting and Applied Molecular Experimentation (NUBEM) Center on Health Science at INTA University Center \u2013 UNINTA Sobral Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benise Ferreira","family":"da Silva","sequence":"additional","affiliation":[{"name":"Center For Bioprospecting and Applied Molecular Experimentation (NUBEM) Center on Health Science at INTA University Center \u2013 UNINTA Sobral Brazil"},{"name":"Northeast Network of Biotechnology Program (RENORBIO) State University of Cear\u00e1 Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wildson Max Barbosa","family":"da Silva","sequence":"additional","affiliation":[{"name":"Chemistry Program State University Vale Do Acara\u00fa, Sobral Campus. Graduate Program in Biotechnology, Federal University of Cear\u00e1 Sobral Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Alves","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Center For Bioprospecting and Applied Molecular Experimentation (NUBEM) Center on Health Science at INTA University Center \u2013 UNINTA Sobral Brazil"},{"name":"Laboratory of Biofilms and Antimicrobial Agents (LaBAM) Faculty of Medicine at INTA University Center \u2013 UNINTA Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0148-8688","authenticated-orcid":false,"given":"Renata Albuquerque","family":"Costa","sequence":"additional","affiliation":[{"name":"Center For Bioprospecting and Applied Molecular Experimentation (NUBEM) Center on Health Science at INTA University Center \u2013 UNINTA Sobral Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7111-1264","authenticated-orcid":false,"given":"Patr\u00edcia Yoshida","family":"Faccioli\u2010Martins","sequence":"additional","affiliation":[{"name":"Brazilian Agricultural Research Corporation \u2010 Embrapa Goats and Sheep Km 4 Rodovia Mo\u00e9sio Loiola De Melo J\u00fanior Sobral Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2766-3790","authenticated-orcid":false,"given":"Selene Maia","family":"de Morais","sequence":"additional","affiliation":[{"name":"Cear\u00e1 State University, Post\u2010Graduate Program in Veterinary Sciences (PPGCV) Fortaleza Cear\u00e1 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