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Drug repurposing offers a pragmatic strategy to identify novel candidates, including those from Traditional Chinese Medicine (TCM). Here, a gene signature\u2013guided repurposing approach was applied to transcriptomic data using Limma and weighted gene coexpression network analysis to define MM\u2010associated hub genes, followed by diagnostic and prognostic evaluation. Coremine Medical screening identified\n Camellia sinensis<\/jats:italic>\n root (CSR) and\n Ginkgo biloba<\/jats:italic>\n leaves (GBL) as promising candidates. CSR and GBL extracts inhibited MM cell proliferation with IC\n 50<\/jats:sub>\n values of 1.54\u00a0mg\/mL and 1.79\u00a0mg\/mL, respectively, and induced G2\/M cell cycle arrest with cyclin B1 downregulation. Apoptosis assays showed increased cell death and Bcl\u20102\/Bax modulation. Wnt\/\u03b2\u2010catenin signaling was suppressed, correlating with cell cycle arrest and apoptosis. HPLC analysis revealed that CSR is rich in amino acids and flavanols, including L\u2010theanine and epicatechin, while GBL contains flavonol glycosides and terpene lactones, such as quercetin, kaempferol, isorhamnetin, ginkgolide A\u2013C, and bilobalide. These results indicate that CSR and GBL exert selective anti\u2010myeloma activity via Wnt\/\u03b2\u2010catenin\u2013mediated cell cycle arrest and apoptosis, highlighting their potential as repurposing candidates for MM.\n <\/jats:p>","DOI":"10.1002\/cbdv.71526","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T17:36:00Z","timestamp":1785087360000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Repurposing\n Camellia sinensis<\/i>\n Roots and\n Ginkgo biloba<\/i>\n Leaves for Multiple Myeloma via Wnt\/\u03b2\u2010Catenin\u2013Dependent Cell Cycle Arrest and Apoptosis"],"prefix":"10.1002","volume":"23","author":[{"given":"Mingge","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacy the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou China"},{"name":"School of Pharmacy Henan University of Chinese Medicine Zhengzhou 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