{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:09:18Z","timestamp":1788858558649,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21807089"],"award-info":[{"award-number":["21807089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    For decades, natural product\u2010derived insect repellents have been a major focus of research. Aconitine, a diterpene alkaloid isolated from\n                    <jats:italic>Aconitum<\/jats:italic>\n                    plants, exhibits not only significant antifeedant activity but also potent toxicological effects against certain insects. In this study, 48 novel aconitine derivatives were synthesized via esterification of the C3\u2010hydroxyl group. Among them, compound\n                    <jats:bold>A4<\/jats:bold>\n                    demonstrated optimum antifeedant activity with an AFC\n                    <jats:sub>50<\/jats:sub>\n                    value of 4.91 \u00b5g\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , surpassing that of the parent compound aconitine (AFC\n                    <jats:sub>50<\/jats:sub>\n                    = 11.65 \u00b5g\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ) and the positive control Azadirachtin (AFC\n                    <jats:sub>50<\/jats:sub>\n                    = 5.57 \u00b5g\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ). Meanwhile, compound\n                    <jats:bold>A10<\/jats:bold>\n                    exhibited the strongest cytotoxicity (IR = 84.71%, IC\n                    <jats:sub>50<\/jats:sub>\n                    = 31.51 \u00b5M), comparable to the positive control chlorfenapyr (IR = 88%, IC\n                    <jats:sub>50<\/jats:sub>\n                    = 3.53 \u00b5M). Structure\u2013activity relationship analysis revealed that medium\u2010length aliphatic chains (C5\u2010C8), electron\u2010withdrawing groups at the\n                    <jats:italic>para<\/jats:italic>\n                    position of benzene ring, and heterocyclic substituents could significantly enhance the antifeedant activity. Cytotoxicity assays and morphological observations indicated typical apoptotic characteristics, which were further confirmed by fluorescence staining and flow cytometry. Thus, this study suggests that the synthesized derivatives possess promising development as advanced insect repellents. This work provides a new structural framework for the development of potent, natural product\u2010based insect antifeedants and offers insights into their potential mode of action.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71527","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:02:35Z","timestamp":1786719755000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, Synthesis, Antifeedant Activity, and Mechanistic Research of Aconitine Derivatives"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5423-4708","authenticated-orcid":false,"given":"Lin","family":"Chen","sequence":"first","affiliation":[{"name":"School of Life Science and Engineering Southwest Jiaotong University  Chengdu Sichuan People's Republic of China"},{"name":"Innovation Center for Small\u2010Molecule Natural Drugs Yibin Institute of Southwest Jiaotong University Yibin Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Pei","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Life Science and Engineering Southwest Jiaotong University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010En","family":"Fu","sequence":"additional","affiliation":[{"name":"School of Life Science and Engineering Southwest Jiaotong University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Life Science and Engineering Southwest Jiaotong University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Life Science and Engineering Southwest Jiaotong University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian\u2010Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Life Science and Engineering Southwest Jiaotong University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cropro.2007.01.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cropro.2021.105678"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/agriculture12050600"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2017.03.034"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecolind.2019.105853"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.agsy.2016.01.004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodqual.2013.08.008"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/insects16020136"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41348\u2010025\u201001177\u2010z"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26164835"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.16801\/j.issn.1008\u20107303.2023.0052"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1572\u20105995(02)80020\u20105"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.7539\/j.issn.1672\u20102981.2016.05.016"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.19540\/j.cnki.cjcmm.20230122.202"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2016.1240207"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.7b00380"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X1501001216"},{"key":"e_1_2_9_19_1","first-page":"35","article-title":"Preliminary Studies on Diterpene Alkaloids as Insecticidal Agents","volume":"2","author":"Meng Z. 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