{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:09:28Z","timestamp":1788858568117,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22267022"],"award-info":[{"award-number":["22267022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Phlomoides melanantha<\/jats:italic>\n                    , a perennial herb belonging to the genus\n                    <jats:italic>Phlomoides<\/jats:italic>\n                    within the Lamiaceae family, has not been previously studied for its chemical constituents. In this research, a phytochemical investigation on the whole plant of\n                    <jats:italic>P. melanantha<\/jats:italic>\n                    led to the isolation of eleven glycosides, including five novel iridoid glycosides named phlomomelanosides A\u2013E (\n                    <jats:bold>1\u20135<\/jats:bold>\n                    ) and six known analogues (\n                    <jats:bold>6\u201311<\/jats:bold>\n                    ). The structures and relative configurations of these isolated compounds were determined using high\u2010resolution mass spectrometry and detailed 1D and 2D nuclear magnetic resonance techniques. Additionally, the absolute configurations of\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>4<\/jats:bold>\n                    , and\n                    <jats:bold>5<\/jats:bold>\n                    were determined by comparing experimental and calculated electronic circular dichroism spectra. The antioxidant properties of all isolated compounds were evaluated using the 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl radical scavenging assay. Compound\n                    <jats:bold>4<\/jats:bold>\n                    exhibited moderate scavenging activity, with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 107.32 \u00b1 4.29 \u00b5M. Furthermore, all compounds were evaluated for their ability to inhibit\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010glucosidase, but none demonstrated significant inhibitory effects. This work expands the known chemical diversity of iridoid glycosides in the\n                    <jats:italic>Phlomoides<\/jats:italic>\n                    genus and represents the first report on the chemical constituents and biological activities of\n                    <jats:italic>P. melanantha<\/jats:italic>\n                    , providing a foundation for future studies on its potential medicinal applications.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71536","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:13:28Z","timestamp":1785431608000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phlomomelanosides A\u2013E, Five New Iridoid Glycosides From the Whole Plant of\n                    <i>Phlomoides melanantha<\/i>\n                    and Their Biological Activities"],"prefix":"10.1002","volume":"23","author":[{"given":"Dan","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of Ethnic Medicine Resource Chemistry Ministry of Education Yunnan Minzu University  Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Yan","family":"Qi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ethnic Medicine Resource Chemistry Ministry of Education Yunnan Minzu University  Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Nian","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ethnic Medicine Resource Chemistry Ministry of Education Yunnan Minzu University  Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ethnic Medicine Resource Chemistry Ministry of Education Yunnan Minzu University  Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2526-1269","authenticated-orcid":false,"given":"Xing\u2010De","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ethnic Medicine Resource Chemistry Ministry of Education Yunnan Minzu University  Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8359-9853","authenticated-orcid":false,"given":"Gan\u2010Peng","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ethnic Medicine Resource Chemistry Ministry of Education Yunnan Minzu University  Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095\u20108339.1982.tb00373.x"},{"key":"e_1_2_9_3_1","first-page":"439","volume-title":"Flora Reipublicae Popularis Sinicae","author":"Wu Z. Y.","year":"1977"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.03.040"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.02.035"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21040461"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2019.1677650"},{"key":"e_1_2_9_8_1","unstructured":"Y. K.Kang \u201cComposition Containing Extracts of Phlomis umbrosa turcz andCynanchum wilfordiias Active Ingredients for Stimulating Motor Function and Muscles \u201d RU2694736C1 2019."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3329\/bjpt.v12i1.607"},{"key":"e_1_2_9_10_1","first-page":"5584","article-title":"Study on the Hypoglycemic Activity of Flavonoids in Phlomoides tuberosa (L.) Moench","volume":"33","author":"Yang Y. B.","year":"2018","journal-title":"China Journal of Traditional Chinese Medicine and Pharmacy"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031\u20109422(00)94777\u20100"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.07.035"},{"key":"e_1_2_9_13_1","first-page":"106","article-title":"Study on the Oil Composition and Its Bioactivityies of the Leaves of Phlomoides umbrosa","volume":"29","author":"Tian G. 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