{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:05:48Z","timestamp":1785330348557,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YEE0104100"],"award-info":[{"award-number":["2025YEE0104100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In order to isolate and characterize enantiomeric compounds from the roots of\n                    <jats:italic>Prangos pabularia<\/jats:italic>\n                    the dichloromethane extract was extensively fractionated by column chromatography, flash, semi\u2010preparative high performance liquid chromatography (HPLC), and chiral HPLC. Six pairs of enantiomers were isolated from dichloromethane extracts using preparative chiral HPLC. The absolute configurations of the isolated isomers were identified using circular dichroism (CD). The anti\u2010vitiligo activities of the corresponding\n                    <jats:italic>(S)\u2010<\/jats:italic>\n                    and\n                    <jats:italic>(R)<\/jats:italic>\n                    \u2010enantiomers were assessed by determining their tyrosinase activation rates. (\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010Pangelin\n                    <jats:bold>9<\/jats:bold>\n                    (PPE19\u20101) showed higher activity with 125.42% than (\n                    <jats:italic>R<\/jats:italic>\n                    )\u2010pangelin\n                    <jats:bold>10<\/jats:bold>\n                    (PPE19\u20102) with 120.6%, while the positive control (8\u2010methoxypsoralen) resulted in 122.3%. The percentage of activation rate of (\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010oxypeucidanin hydrate\n                    <jats:bold>1<\/jats:bold>\n                    (PPE4\u20101) was 119.74%, while it was 110.01% for (\n                    <jats:italic>R<\/jats:italic>\n                    ) oxypeucidanin hydrate\n                    <jats:bold>2<\/jats:bold>\n                    (PPE4\u20102). We conclude that the (\n                    <jats:italic>S, R<\/jats:italic>\n                    ) enantiomers of pangelin and oxypeucidanin hydrate (\n                    <jats:italic>S, R<\/jats:italic>\n                    ) may be useful as pigmentation\u2010promoting agents for the treatment of vitiligo.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71537","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T18:01:47Z","timestamp":1785261707000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chiral Coumarin Enantiomers From\n                    <i>Prangos pabularia<\/i>\n                    Roots: Absolute Configuration, Tyrosinase Activation, and Anti\u2010Vitiligo Potential in B16F10 Cells"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1139-7917","authenticated-orcid":false,"given":"Sunbula","family":"Atolikshoeva","sequence":"first","affiliation":[{"name":"Key Laboratory of Plant Resources and Chemistry in Arid Regions Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Urumqi P. R. China"},{"name":"Research Institution \u201cChinese\u2010Tajik Innovation Center for Natural Products\u201d National Academy of Sciences of Tajikistan Dushanbe Tajikistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4597-4047","authenticated-orcid":false,"given":"Sodik","family":"Numonov","sequence":"additional","affiliation":[{"name":"Key Laboratory of Plant Resources and Chemistry in Arid Regions Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Urumqi P. R. China"},{"name":"Research Institution \u201cChinese\u2010Tajik Innovation Center for Natural Products\u201d National Academy of Sciences of Tajikistan Dushanbe Tajikistan"},{"name":"Department of Medicinal Chemistry Institute of Biochemistry Samarkand State University  Samarkand Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7990-1295","authenticated-orcid":false,"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Plant Resources and Chemistry in Arid Regions Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Urumqi P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1122-7048","authenticated-orcid":false,"given":"Jiangyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Plant Resources and Chemistry in Arid Regions Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Urumqi P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayire","family":"Nueraihemaiti","sequence":"additional","affiliation":[{"name":"Key Laboratory of Plant Resources and Chemistry in Arid Regions Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Urumqi P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isomiddin","family":"Gulmurodov","sequence":"additional","affiliation":[{"name":"Key Laboratory of Plant Resources and Chemistry in Arid Regions Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Urumqi P. R. China"},{"name":"Research Institution \u201cChinese\u2010Tajik Innovation Center for Natural Products\u201d National Academy of Sciences of Tajikistan Dushanbe Tajikistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6009-2996","authenticated-orcid":false,"given":"Xin","family":"Xuelei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Plant Resources and Chemistry in Arid Regions Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Urumqi P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2328-3974","authenticated-orcid":false,"given":"Maitinuer","family":"Maiwulanjiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Plant Resources and Chemistry in Arid Regions Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Urumqi P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7449-0936","authenticated-orcid":false,"given":"Khurshed","family":"Bozorov","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry Institute of Biochemistry Samarkand State University  Samarkand Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrohimjon","family":"Askarov","sequence":"additional","affiliation":[{"name":"Department of Chemistry Andijan State University  Andijan Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8893-8743","authenticated-orcid":false,"given":"Guangmin","family":"Yao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Plant Resources and Chemistry in Arid Regions Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Urumqi P. R. China"},{"name":"Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of Pharmacy Tongji Medical College Huazhong University of Science and Technology  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4652-6879","authenticated-orcid":false,"given":"Haji Akber","family":"Aisa","sequence":"additional","affiliation":[{"name":"Key Laboratory of Plant Resources and Chemistry in Arid Regions Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Urumqi P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"68","article-title":"A Review on Ethnobotany, Phytochemical and Pharmacological Dynamics of Prangos pabularia Lindl","volume":"13","author":"Sharma N.","year":"2013","journal-title":"Journal of Natural Remedies"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0367\u2010326X(99)00163\u2010X"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2022.2102627"},{"key":"e_1_2_9_5_1","first-page":"437","article-title":"Perfum","volume":"54","author":"Sarin Y. K.","year":"1963","journal-title":"Essential Oils Recipies"},{"key":"e_1_2_9_6_1","first-page":"537","article-title":"The Anti\u2010Lipid Peroxidative, Metal Chelating, and Radical Scavenging Properties of the Fruit Extracts From Endemic Prangos meliocarpoides Boiss Var. meliocarpoides","volume":"29","author":"Oke\u2010Altuntas F.","year":"2016","journal-title":"Gazi University Journal of Science"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/chem\u20102018\u20100051"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786410802588667"},{"key":"e_1_2_9_9_1","first-page":"244","article-title":"Fast Determination of Prangos uloptera Essential Oil by Nanoporous Silica\u2010Polypyrrole SPME Fiber","volume":"23","author":"Abolghasemi M. M.","year":"2012","journal-title":"Chemija"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2003.09.004"},{"key":"e_1_2_9_11_1","first-page":"185","article-title":"Medicinal Plants of Cold Desert Ladakh Used in the Treatment of Stomach Disorders","volume":"8","author":"Ballabh B.","year":"2007","journal-title":"Indian Journal of Traditional Knowledge"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031\u20109422(02)00023\u20107"},{"key":"e_1_2_9_13_1","first-page":"392","article-title":"Bioactivity of Aviprin and Aviprin\u20103''\u2010O\u2010Glucoside, Two Linear Furanocoumarins From Apiaceae","volume":"36","author":"Razavi S. M.","year":"2010","journal-title":"Bioorganicheskaia Khimiia"},{"key":"e_1_2_9_14_1","first-page":"47","article-title":"Standardization and Phytochemical Evaluation of the Aerial Parts of Prangos pabularia","volume":"1","author":"Sharma N.","year":"2013","journal-title":"Journal of Pharmacognosy and Phytochemistry"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27041279"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26082346"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17091252"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S180960"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23071723"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2017.06.035"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2022.121034"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00369A"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22010158"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/c000408c"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr020071b"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.59566\/IJBS.2006.2085"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/app122110909"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lmd.2024.100008"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.20930"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30320"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2022.113313"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23020492"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.22145"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201107204"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC01630G"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201107204"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2017.1413558"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2025.2554309"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735\u20105362.329922"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2017.1413558"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2018.1548625"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02975883"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031\u20109422(00)80344\u20101"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11164\u2010017\u20103023\u20103"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1515\/hc\u20102017\u20100256"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/10426507.2018.1487968"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23147959"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71537","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.71537","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:28:03Z","timestamp":1785328083000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.71537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":46,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/cbdv.71537"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.71537","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71537"}}