{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:09:27Z","timestamp":1788858567490,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We report the synthesis and assessment of novel benzimidazole\u2013triazole scaffolds (\n                    <jats:bold>4a\u20134j<\/jats:bold>\n                    ) as antimicrobial\/antitubercular medicines. Two\u2010pot condensation processes were used to synthesize the target compounds. Spectroscopic techniques such as mass spectrometry and nuclear magnetic resonance (\n                    <jats:sup>1<\/jats:sup>\n                    H\/\n                    <jats:sup>13<\/jats:sup>\n                    C) spectroscopy were used to characterize the synthesized molecules. The remarkable in vitro activity of compounds\n                    <jats:bold>4d<\/jats:bold>\n                    and\n                    <jats:bold>4h<\/jats:bold>\n                    (MICs 2.65\u00a0\u00b1\u00a01.10 and 2.57\u00a0\u00b1\u00a00.34\u00a0\u00b5M) is comparable activity to conventional drug Streptomycin (MIC\u00a0=\u00a02.90\u00a0\u00b1\u00a00.47\u00a0\u00b5M), indicates that these are promising new class of anti\u2010tubercular medicines. Among the tested molecules,\n                    <jats:bold>4h<\/jats:bold>\n                    and\n                    <jats:bold>4i<\/jats:bold>\n                    exhibited exceptional antibacterial activity with minimum inhibitory concentrations of 3.15\u00a0\u00b1\u00a00.23 and 4.81\u00a0\u00b1\u00a00.18\u00a0\u00b5M against the\n                    <jats:italic>Bacillus cereus<\/jats:italic>\n                    , when compared to Moxifloxacin (MIC\u00a0=\u00a03.52\u00b10.60\u00a0\u00b5M). Antifungal profiles showed that compounds\n                    <jats:bold>4d<\/jats:bold>\n                    and\n                    <jats:bold>4i<\/jats:bold>\n                    had better antifungal inhibitory potency against\n                    <jats:italic>Fusarium oxysporum<\/jats:italic>\n                    with MIC values of 4.91\u00a0\u00b1\u00a01.51 and 3.68\u00a0\u00b1\u00a00.12\u00a0\u00b5M, respectively. Solid binding affinities (\u22126.85 to \u22129.26\u00a0kcal\/mol) with the\n                    <jats:italic>Mycobacterium<\/jats:italic>\n                    TB DprE1 (PDB code: 4FDN) and methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (PDB ID: 1MWR) through important active sites of H\u2212bond and hydrophobic interaction residues are shown by the in silico molecular docking studies, which offer solid support for their mode of action.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71539","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T03:46:27Z","timestamp":1785555987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Antitubercular, Antimicrobial Potency, ADME\u2010T Calculations and Docking Studies of 1,2,4\u2010Triazole\u2010Bearing Benzimidazoles"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9551-9873","authenticated-orcid":false,"given":"Khaja Mohiddin","family":"Shaik","sequence":"first","affiliation":[{"name":"Department of Chemistry, School of Applied Sciences REVA University  Bengaluru Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komala","family":"Pandurangan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Applied Sciences REVA University  Bengaluru Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7156-5688","authenticated-orcid":false,"given":"Srinu","family":"Bhoomandla","sequence":"additional","affiliation":[{"name":"Department of Chemistry Geethanjali College of Engineering and Technology  Medchal Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1017-9182","authenticated-orcid":false,"given":"Kishore","family":"Mendam","sequence":"additional","affiliation":[{"name":"Department of Zoology Dr. B. 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Ambedkar Open University  Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6157-5374","authenticated-orcid":false,"given":"Punna Reddy","family":"Ullapu","sequence":"additional","affiliation":[{"name":"Research Institute Dong\u2010A ST Co., Ltd  Yongin South 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