{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:09:25Z","timestamp":1788858565445,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    To develop citral\u2010based botanical fungicides, 112 previously reported derivatives across 5 series were evaluated in vitro against\n                    <jats:italic>Colletotrichum fructicola<\/jats:italic>\n                    . SAR analysis identified the citral\u2010thiourea series as the most potent group, with 3\u2010methoxy derivative\n                    <jats:bold>c18<\/jats:bold>\n                    showing the highest intraseries activity. Notably, intermediates\n                    <jats:bold>d<\/jats:bold>\n                    (EC\n                    <jats:sub>50<\/jats:sub>\n                    = 0.7474\u00a0mg\/L, EC\n                    <jats:sub>90<\/jats:sub>\n                    = 6.0319\u00a0mg\/L) and\n                    <jats:bold>g<\/jats:bold>\n                    (EC\n                    <jats:sub>50<\/jats:sub>\n                    = 0.1073\u00a0mg\/L, EC\n                    <jats:sub>90<\/jats:sub>\n                    = 0.6244\u00a0mg\/L) demonstrated exceptional efficacy, significantly outperforming commercial chlorothalonil (EC\n                    <jats:sub>50<\/jats:sub>\n                    = 1.4382\u00a0mg\/L, EC\n                    <jats:sub>90<\/jats:sub>\n                    = 268.5969\u00a0mg\/L), with intermediate\n                    <jats:bold>g<\/jats:bold>\n                    emerging as the most potent compound overall. A predictive QSAR model was successfully constructed (\n                    <jats:italic>\n                      R\n                      <jats:sup>2<\/jats:sup>\n                    <\/jats:italic>\n                    = 0.8345), revealing that lower polarity, enhanced electronic stability of carbon\u2013hydrogen bonds, higher localized solvation energy, and minimized steric hindrance favor antifungal potency. Furthermore, MTT assays confirmed that derivative\n                    <jats:bold>g<\/jats:bold>\n                    exhibits low cytotoxicity toward human liver and kidney cells, substantially lower than raw citral. This work provides a solid theoretical framework for designing highly active inhibit\n                    <jats:italic>C. fructicola<\/jats:italic>\n                    agents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71542","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T17:28:06Z","timestamp":1786210086000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SAR and QSAR Studies of Citral\u2010Based Derivatives Against\n                    <i>Colletotrichum fructicola<\/i>"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4218-3558","authenticated-orcid":false,"given":"Min","family":"Xiao","sequence":"first","affiliation":[{"name":"College of Forestry Key Laboratory of National Forestry and Grassland Administration on Woody Fragrance and Flavor Jiangxi Agricultural University Jiangxi Provincial Key Laboratory of Improved Variety Breeding and Efficient Utilization of Native Tree Species  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowen","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Forestry Key Laboratory of National Forestry and Grassland Administration on Woody Fragrance and Flavor Jiangxi Agricultural University Jiangxi Provincial Key Laboratory of Improved Variety Breeding and Efficient Utilization of Native Tree Species  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagen","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Forestry Jiangxi Agricultural University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Soil and Water Conservation Jiangxi Provincial Engineering Research Center For Seed\u2010Breeding and Utilization of Camphor Trees Jiangxi University of Water Resources and Electric Power  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengliang","family":"Liao","sequence":"additional","affiliation":[{"name":"College of Forestry Key Laboratory of National Forestry and Grassland Administration on Woody Fragrance and Flavor Jiangxi Agricultural University Jiangxi Provincial Key Laboratory of Improved Variety Breeding and Efficient Utilization of Native Tree Species  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences University of Michigan\u2010Flint  Flint Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zeng","sequence":"additional","affiliation":[{"name":"School of Soil and Water Conservation Jiangxi Provincial Engineering Research Center For Seed\u2010Breeding and Utilization of Camphor Trees Jiangxi University of Water Resources and Electric Power  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangxing","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Forestry Key Laboratory of National Forestry and Grassland Administration on Woody Fragrance and Flavor Jiangxi Agricultural University Jiangxi Provincial Key Laboratory of Improved Variety Breeding and Efficient Utilization of Native Tree Species  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.14067\/j.cnki.1673\u20109272.2012.02.013"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.13428\/j.cnki.fjlk.2015.02.033"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.19692\/j.cnki.gfs.2015.01.002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.19692\/j.cnki.gfs.2013.04.010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof10090630"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants13192743"},{"issue":"3","key":"e_1_2_9_8_1","first-page":"222","article-title":"Main Diseases and Insect Pests of Camellia leifera and Its Control Techniques","volume":"42","author":"Chen H. 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