{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:09:19Z","timestamp":1788858559302,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The ethanol extract of\n                    <jats:italic>H. capitata<\/jats:italic>\n                    stems and flowers were prepared using the hot extraction method with 96% ethanol for chemical composition and biological analysis. GC\u2013MS and LC\u2013MS identified 71 compounds across both extracts. The flower extract contained the highest total phenolic content (TPC) (48.47\u00a0\u00b1\u00a02.03 mg GAE\/g), while the stem extract showed higher total flavonoid content (TFC)\u00a0(9.21\u00a0\u00b1\u00a00.10 mg QE\/g), and total triterpenoid contents (TTC) (27.01\u00a0\u00b1\u00a01.06 mg OAE\/g). The flower extract demonstrated stronger antioxidant activity than the stem extract, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 18.00\u00a0\u00b1\u00a00.28 \u00b5g\/mL (DPPH) and 3.81\u00a0\u00b1\u00a00.04 \u00b5g\/mL (ABTS). It also exhibited antifungal activity against four pathogenic fungal strains (MIC: 500\u20131000 \u00b5g\/mL). In addition, both extracts showed\n                    <jats:italic>\u03b1\u2010<\/jats:italic>\n                    glucosidase inhibitory activity, particularly the flower extract (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a05.87\u00a0\u00b1\u00a00.18 \u00b5g\/mL), compared with the stem extract (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a023.27\u00a0\u00b1\u00a00.77 \u00b5g\/mL), suggesting the presence of constituents associated with antidiabetic potential. Molecular docking suggested that key compounds\u22121,2\u2010cyclohexanedicarboxylic acid bis(2\u2010ethylhexyl) ester (stem) and 6\u03b2\u2010acetoxy\u20105\u2010epilimonin (flower)\u2212may contribute to enzyme inhibition, with binding energies of \u221210.0 and \u22129.4 kcal\/mol, respectively. Overall, these findings suggest that\n                    <jats:italic>H. capitata<\/jats:italic>\n                    , particularly its flowers, represents a promising source of bioactive compounds for further isolation and in vivo validation.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71546","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T20:12:47Z","timestamp":1785960767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phytochemical Characterization, In Vitro Antifungal and Antidiabetic Activities of Stem and Flower From Ethanol Extract of\n                    <i>Hyptis capitata<\/i>"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2626-0834","authenticated-orcid":false,"given":"Dung Nguyen","family":"Tien","sequence":"first","affiliation":[{"name":"Faculty of Biology and Biotechnology University of Science, VNU\u2010HCM  Ho Chi Minh City Vietnam"},{"name":"Laboratory of Biochemistry, Faculty of Biology and Biotechnology University of Science  Ho Chi Minh City Vietnam"},{"name":"Vietnam National University  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phong Pham","family":"Thanh","sequence":"additional","affiliation":[{"name":"Faculty of Biology and Biotechnology University of Science, VNU\u2010HCM  Ho Chi Minh City Vietnam"},{"name":"Laboratory of Biochemistry, Faculty of Biology and Biotechnology University of Science  Ho Chi Minh City Vietnam"},{"name":"Vietnam National University  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1662-2053","authenticated-orcid":false,"given":"Chau Dao Minh","family":"Huynh","sequence":"additional","affiliation":[{"name":"Faculty of Biology and Biotechnology University of Science, VNU\u2010HCM  Ho Chi Minh City Vietnam"},{"name":"Vietnam National University  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuong Pham","family":"Quoc","sequence":"additional","affiliation":[{"name":"Biotechnology Center of Ho Ch\u00ed Minh City  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao Vo","family":"Thien","sequence":"additional","affiliation":[{"name":"Faculty of Biology and Biotechnology University of Science, VNU\u2010HCM  Ho Chi Minh City Vietnam"},{"name":"Laboratory of Biochemistry, Faculty of Biology and Biotechnology University of Science  Ho Chi Minh City Vietnam"},{"name":"Vietnam National University  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngan Truong Phuc","family":"Thoai","sequence":"additional","affiliation":[{"name":"Faculty of Biology and Biotechnology University of Science, VNU\u2010HCM  Ho Chi Minh City Vietnam"},{"name":"Vietnam National University  Ho Chi Minh City Vietnam"},{"name":"Laboratory of Biosensors, Faculty of Biology and Biotechnology University of Science  Ho Chi Minh City Vietnam"},{"name":"Laboratory of Molecular Biotechnology University of Science  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5832-8082","authenticated-orcid":false,"given":"Thang Truong","family":"Le","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine National Taiwan University  Taipei Taiwan"},{"name":"Genome and Systems Biology Degree Program National Taiwan University and Academia Sinica  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2782-5232","authenticated-orcid":false,"given":"Hieu","family":"Tran\u2010Van","sequence":"additional","affiliation":[{"name":"Faculty of Biology and Biotechnology University of Science, VNU\u2010HCM  Ho Chi Minh City Vietnam"},{"name":"Vietnam National 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