{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:09:02Z","timestamp":1788858542836,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this study, we evaluated the cytogenotoxicity of strontium ranelate (SrR), an important therapeutic agent used in the treatment of postmenopausal osteoporosis, alone, as well as in combined treatment with resveratrol (RSV), a natural polyphenolic compound with protective properties, in standardized genetic toxicology assays. The concentrations selected for the tests included vehicle control; 10 \u00b5M SrR; 200 \u00b5M SrR; 1000 \u00b5M SrR; 10 \u00b5M RSV; 25 \u00b5M RSV; 80 \u00b5M RSV; and 200 \u00b5M SrR + 80 \u00b5M RSV, with RSV\u2010containing treatments prepared using 2% DMSO as vehicle. Preliminary toxicological and cytogenotoxic screening was conducted using the\n                    <jats:italic>Artemia salina<\/jats:italic>\n                    and\n                    <jats:italic>Allium cepa<\/jats:italic>\n                    bioassays, both performed in quintuplicate. Active\n                    <jats:italic>A. salin<\/jats:italic>\n                    a nauplii were transferred to test tubes containing the selected concentrations and treated for 24\u00a0h. For the\n                    <jats:italic>A. cepa<\/jats:italic>\n                    assay, forty bulbs were randomly divided into eight groups and exposed to the previously described treatments. Treatments with SrR applied alone induced toxic effects in\n                    <jats:italic>A. salina<\/jats:italic>\n                    and exhibited clastogenic and aneugenic effects in\n                    <jats:italic>A. cepa<\/jats:italic>\n                    . In contrast, RSV and the combined treatment were not cytotoxic and were still able to reduce the DNA damage induced by SrR, thus demonstrating antigenotoxic potential over SrR.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71547","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T20:26:18Z","timestamp":1785961578000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Toxicological and Cytogenetic Screening of Strontium Ranelate Alone and in Combination With Resveratrol"],"prefix":"10.1002","volume":"23","author":[{"given":"Dhy\u00f4vanna Carine Cardoso","family":"Beir\u00e3o","sequence":"first","affiliation":[{"name":"Laboratory of Mineralized Tissue and Histology Research Department of Morphology and Genetics Paulista School of Medicine Federal University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kauan Ferreira da","family":"Rocha","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicological Genetics (LabGetox), Center for Research in Medicinal Plants (NPPM) Federal University of Piau\u00ed Teresina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6862-6497","authenticated-orcid":false,"given":"Paulo Michel Pinheiro","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Oncology (LOE), Department of Physiology and Pharmacology, Drug Development Research Center (NPDM) Federal University of Cear\u00e1 Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4370-9111","authenticated-orcid":false,"given":"Rejane Daniele","family":"Reginato","sequence":"additional","affiliation":[{"name":"Laboratory of Mineralized Tissue and Histology Research Department of Morphology and Genetics Paulista School of Medicine Federal University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0286-0218","authenticated-orcid":false,"given":"Elis\u00e2ngela Cl\u00e1udia Alves de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicological Genetics (LabGetox), Center for Research in Medicinal Plants (NPPM) Federal University of Piau\u00ed Teresina Brazil"},{"name":"Department of Biochemistry and Pharmacology Federal University of Piau\u00ed Teresina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/ciia.2006.1.4.367"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2021.116107"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e11880"},{"key":"e_1_2_10_5_1","unstructured":"Q.Sun F.Liu J.Fang 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