{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:04:47Z","timestamp":1785330287296,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100017685","name":"Mitani Foundation for Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017685","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Four undescribed chromane\u2010type meroterpenoids, sargasilides H\u2013K (\n                    <jats:bold>1\u20134<\/jats:bold>\n                    ), were isolated from the brown alga\n                    <jats:italic>Sargassum siliquastrum<\/jats:italic>\n                    . Their structures were elucidated by comprehensive spectroscopic analyses, and their absolute configurations were partially established by electronic circular dichroism and the modified Mosher's method. The inhibitory effects of\n                    <jats:bold>1\u20134<\/jats:bold>\n                    against amyloid\u2010\u03b242 aggregation were evaluated using a thioflavin T fluorescence assay. Among them, sargasilide J (\n                    <jats:bold>3<\/jats:bold>\n                    ) exhibited the strongest activity. Furthermore, compound\n                    <jats:bold>3<\/jats:bold>\n                    significantly delayed paralysis in a transgenic\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    model expressing amyloid\u2010\u03b242. These findings provide further insight into the structural features governing amyloid\u2010\u03b242 aggregation inhibition in chromane\u2010type meroterpenoids.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71550","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T17:54:16Z","timestamp":1785261256000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Four Undescribed Chromane\u2010Type Meroterpenoids From\n                    <i>Sargassum siliquastrum<\/i>\n                    and Their Inhibitory Activity Against Amyloid\u2010\u03b242 Aggregation"],"prefix":"10.1002","volume":"23","author":[{"given":"Mafumi","family":"Horiuchi","sequence":"first","affiliation":[{"name":"Graduate School of Bioresources and Environmental Science Ishikawa Prefectural University  Nonoichi Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joh","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Graduate School of Science and Technology University of Tsukuba  Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9778-8057","authenticated-orcid":false,"given":"Hideyuki","family":"Shigemori","sequence":"additional","affiliation":[{"name":"Institute of Life and Environmental Sciences University of Tsukuba  Tsukuba Ibaraki Japan"},{"name":"Microbiology Research Center For Sustainability (MiCS) University of Tsukuba  Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0540-4306","authenticated-orcid":false,"given":"Yasuki","family":"Higashimura","sequence":"additional","affiliation":[{"name":"Graduate School of Bioresources and Environmental Science Ishikawa Prefectural University  Nonoichi Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6780-4538","authenticated-orcid":false,"given":"Mitsuhiro","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Graduate School of Bioresources and Environmental Science Ishikawa Prefectural University  Nonoichi Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/md17100590"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/md16090292"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/07388551.2021.2001639"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.117188"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418\u2010024\u201001847\u20106"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418\u2010023\u201001693\u2010y"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418\u2010026\u201002006\u20109"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1246\/cl.1979.277"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/np058003i"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.3c00087"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.56.124"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/membranes6040056"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.51.448"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00011a006"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11130\u2010022\u201000951\u2010w"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bbb\/zbaf058"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(99)09022-9"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.20.9368"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00659"}],"container-title":["Chemistry &amp; 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