{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:09:00Z","timestamp":1788858540776,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Clerodendrum thomsoniae<\/jats:italic>\n                    Balf. f. (Lamiaceae) is commonly known as the bleeding\u2010heart vine or glory tree and traditionally used for treating blood\u2010related disorders. This research investigated the phytochemical constituents, antioxidant capacity, and thrombolytic potential of leaf extracts. Among the extracts, the ethanol extract exhibited the highest total phenolic content, which correlated with its strong antioxidant activity demonstrated through multiple assays including DPPH, hydrogen peroxide, nitric oxide (NO) scavenging, and ferrous ion chelation. The petroleum ether extract showed notable thrombolytic activity by effectively lysing blood clots, achieving 34.52% clot lysis, which was significantly higher than the negative control (7.89%) but lower than the standard drug streptokinase (60.23%). Through\u00a0GC\u2010MS analysis, identified several bioactive compounds including\u00a0sterols and fatty acids, which likely contribute these health benefits. These results suggest that\n                    <jats:italic>C. thomsoniae<\/jats:italic>\n                    leaves are a promising natural alternative for managing cardiovascular disorder\u00a0and oxidative stress. Further in vivo studies and isolation of active compounds are essential.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71553","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:29:56Z","timestamp":1785432596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Phytochemical Investigation, Thrombolytic, and Antioxidant Activity of\n                    <i>Clerodendrum thomsoniae<\/i>\n                    Balf"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-4602","authenticated-orcid":false,"given":"Ajaykumar Rikhabchand","family":"Surana","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy Mahatma Gandhi Vidyamandir Pharmacy College  Nashik Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prathamesh Shyam","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Regulatory Affairs R. C. Patel Institute of Pharmaceutical Education &amp; Research  Dhule Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita Mulchand","family":"Jadhav","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy S.M.B.T. College of Pharmacy  Nashik Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3506-3592","authenticated-orcid":false,"given":"Harsha Iccharm","family":"Narkhede","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry S.M.B.T. College of Pharmacy  Nashik Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj Ramesh","family":"Kumbhare","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry S.M.B.T. College of Pharmacy  Nashik Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonam Pankaj","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, K V N Naik Shikshan Prasarak Santha's Institute of Pharmaceutical Education &amp; Research  Nashik Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Physiology, Hemostasis","author":"LaPelusa A.","year":"2023"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-803550-4.00031-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2594127"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028\u2010015\u20100126\u20109"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5339\/gcsp.2014.46"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(20)30211\u20108"},{"issue":"6","key":"e_1_2_9_8_1","first-page":"430","article-title":"Evaluation of Thrombolytic Potential of Three Medicinal Plants Available in Bangladesh, as a Potent Source of Thrombolytic Compounds","volume":"4","author":"Ramjan A.","year":"2014","journal-title":"Avicenna J phytomedicine"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.71193\/jpci.20250014"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-8258.142671"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.25081\/ripb.2019.v9.3779"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/np9606759"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074\u20107742(07)82016\u20102"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40816\u2010023\u201000353\u20108"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.12980\/APJTB.4.201414B295"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.4334"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/1998870"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.17221\/10664\u2010CJFS"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2019.01.004"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26040975"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/app15052491"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf030045u"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2015.06.018"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010016\u20101461\u2010x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf970975b"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0944\u20107113(00)80015\u2010X"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/179865"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eujim.2018.02.002"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2017.11.002"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7092151"},{"issue":"10","key":"e_1_2_9_31_1","first-page":"228","article-title":"Ethnomedicinal Application, Phytochemistry and Therapeutic Effects of Genus clerodendrum","volume":"3","author":"Ogunlakin A. 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