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In this study, the aqueous\u2013ethanol extract of\n                    <jats:italic>S. cadmica<\/jats:italic>\n                    was evaluated for its antioxidant, cytoprotective, and anti\u2010senescence effects using in vitro and in silico approaches. LC\u2013ESI\u2013MS\/MS analysis identified rosmarinic acid (3447\u00a0\u00b5g\/g), luteolin 7\u2010glucoside (767\u00a0\u00b5g\/g), and luteolin (586\u00a0\u00b5g\/g) as major constituents. The extract exhibited strong antioxidant capacity, particularly in the phosphomolybdenum assay (713.51\u00a0mg TEs\/g), and showed notable radical scavenging activity in ABTS (140.00\u00a0mg TEs\/g) and DPPH (99.20\u00a0mg TEs\/g) assays. In H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced senescent human dermal fibroblasts (HDFa), pre\u2010treatment with the extract significantly reduced senescence\u2010associated \u03b2\u2010galactosidase positivity from 97.15% to 49.12% and improved cell viability. The extract downregulated\n                    <jats:italic>MMP1<\/jats:italic>\n                    and\n                    <jats:italic>MMP3<\/jats:italic>\n                    mRNA expression (0.51\u2010 and 0.66\u2010fold, respectively) while markedly upregulating\n                    <jats:italic>COL1A1<\/jats:italic>\n                    expression (7.48\u2010fold). Molecular docking and MM\/GBSA analyses revealed that luteolin 7\u2010glucoside showed high binding affinities toward MMP1 and MMP3 (\u0394Gdocking = \u22129.06 and \u22129.86\u00a0kcal\/mol; \u0394GMM\/GBSA = \u221237.21 and \u221250.22\u00a0kcal\/mol, respectively). In silico ADMET predictions supported a favorable dermal safety profile. Overall,\n                    <jats:italic>S. cadmica<\/jats:italic>\n                    represents a promising natural source of bioactive compounds with antioxidant and anti\u2010aging potential relevant to skin aging prevention.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71559","type":"journal-article","created":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T16:34:26Z","timestamp":1786293266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ethnopharmacological and Antiaging Evaluation of\n                    <i>Salvia cadmica<\/i>\n                    : Modulation of MMP1\/MMP3 and Collagen in Oxidative Stress\u2010Induced Senescence"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1928-7158","authenticated-orcid":false,"given":"Nilay","family":"Isitez","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Afyonkarahisar Health Sciences University  Afyonkarahisar Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2189-0703","authenticated-orcid":false,"given":"Erman Salih","family":"Istifli","sequence":"additional","affiliation":[{"name":"Faculty of Arts and Sciences Cukurova University  Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5094-2520","authenticated-orcid":false,"given":"Cengiz","family":"Sarikurkcu","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Afyonkarahisar Health Sciences University  Afyonkarahisar Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4319-7558","authenticated-orcid":false,"given":"Sevim Feyza","family":"Erdogmus","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Afyonkarahisar Health Sciences University  Afyonkarahisar Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014\u20104827(65)90211\u20109"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2233"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.07.031"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2020.113113"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/app11209365"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201074715\u20104"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201002420\u20101"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2021.105013"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010biochem\u2010030222\u2010120000"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00104"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab255"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201096623\u2010x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1615\/IntJMedMushrooms"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/bmy003"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1999.4019"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/09637480600798132"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1996.0292"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/1811199a0"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891\u20105849(98)00315\u20103"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1994.1485"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot095505"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100625.2011.01388.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010020\u201003911\u20107"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.20.9363"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398"},{"key":"e_1_2_11_27_1","article-title":"Discovery Studio","author":"Biovia D. 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