{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:09:09Z","timestamp":1788858549259,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:00:00Z","timestamp":1786752000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574239"],"award-info":[{"award-number":["82574239"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The bioactive material basis of\n                    <jats:italic>Raphanus sativus<\/jats:italic>\n                    L. seeds (\n                    <jats:italic>Raphani Semen<\/jats:italic>\n                    ) against ulcerative colitis (UC) remains unclear. This study compared the chemical profiles and anti\u2010colitic efficacy of its nonpolar volatile oil (RSO) and polar ethanol extract (RSEE). Chemical profiling using GC\u2010MS and UPLC\u2010MS\/MS revealed RSO was dominated by phytosterols, whereas RSEE was enriched in phenolic alkaloids, particularly sinapine. In a dextran sulfate sodium (DSS)\u2010induced murine colitis model, RSEE demonstrated superior efficacy in reducing disease activity and restoring mucosal barriers compared to RSO. Biochemically, RSEE significantly suppressed myeloperoxidase (MPO) and pro\u2010inflammatory cytokines while enhancing antioxidant defense. Molecular docking confirmed sinapine as a pivotal compound with high binding affinity for MPO and Keap1. Consequently, the polar fraction is identified as the primary active component, with sinapine serving as the key material basis for treating colitis via oxidative stress modulation.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71560","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T17:09:02Z","timestamp":1786813742000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemical Characterization, Network Pharmacology, Molecular Docking, and Comparative Anti\u2010Colitic Activity of Polar and Nonpolar Fractions From\n                    <i>Raphanus Sativus<\/i>\n                    L. Seeds"],"prefix":"10.1002","volume":"23","author":[{"given":"Wenlin","family":"Chen","sequence":"first","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9459-7378","authenticated-orcid":false,"given":"Yujing","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology  Guangzhou P. R. China"},{"name":"College of Pharmacy Jinan University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duntao","family":"Zu","sequence":"additional","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laiyu","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinbo","family":"He","sequence":"additional","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyin","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology  Guangzhou P. R. 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