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In this study, a hydroalcoholic crude extract of the periderm, an outer renewable bark layer compatible with sustainable collection, was evaluated as an underexplored natural matrix. HPLC\u2013DAD identified taxifolin as the main quantified marker compound, corresponding to 21.1\u00a0mg\/g of dry extract. Untargeted UPLC\u2013QTOF\u2013MS analysis revealed a polyphenol\u2010rich profile, mainly represented by condensed tannins and flavonoids in ESI(\u2212) mode, while terpenoids were more evident in ESI(+) mode. The extract showed concentration\u2010dependent DPPH radical\u2010scavenging activity, with an IC\n                    <jats:sub>50<\/jats:sub>\n                    of 12.31\u00a0\u00b5g\/mL, comparable to ascorbic acid. Comparison with taxifolin tested at concentrations equivalent to those estimated in the extract indicated that taxifolin accounted for only part of the observed antioxidant response. In SH\u2010SY5Y cells, the extract was cytocompatible up to 1\u00a0\u00b5g\/mL and partially counteracted H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced reduction in cell viability within this non\u2010cytotoxic range. TXRF analysis provided a preliminary safety\u2010oriented elemental profile, with regulated elements detected at low levels. Overall, these findings support\n                    <jats:italic>P. pinea<\/jats:italic>\n                    periderm as a renewable Mediterranean source of secondary metabolites with antioxidant potential, while further mechanistic and toxicological studies are required to confirm its functional applicability.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71561","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T17:21:45Z","timestamp":1786209705000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Pinus pinea<\/i>\n                    L. Periderm as a Sustainable Source of Phenolic Bioactives: Integrated Phytochemical, Antioxidant, and Elemental Investigation"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8468-6921","authenticated-orcid":false,"given":"Vlad Sebastian","family":"Popescu","sequence":"first","affiliation":[{"name":"Department of Molecular and Translational Medicine Division of Pharmacology University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7362-3258","authenticated-orcid":false,"given":"Fabjola","family":"Bilo","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Specialties Radiological Sciences and Public Health University of Brescia  Brescia Italy"},{"name":"Department of Mechanical and Industrial Engineering University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7385-7310","authenticated-orcid":false,"given":"Eileen","family":"Mac Sweneey","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine Division of Pharmacology University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3486-2656","authenticated-orcid":false,"given":"Laura","family":"Borgese","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Industrial Engineering University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6007-6184","authenticated-orcid":false,"given":"Gregorio","family":"Peron","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine Division of Pharmacology University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9161-3475","authenticated-orcid":false,"given":"Giulia","family":"Abate","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine Division of Pharmacology University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8862-2896","authenticated-orcid":false,"given":"Andrea","family":"Mastinu","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine Division of Pharmacology University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,8]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"130","volume-title":"European Atlas of Forest Tree Species","author":"Vi\u00f1as R. 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