{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:09:07Z","timestamp":1788858547120,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Chimonanthus salicifolius<\/jats:italic>\n                    has traditionally been used for the treatment of gastrointestinal disorders. In this study, a systematic phytochemical investigation of this plant was conducted, leading to the isolation and identification of two previously undescribed furan glycosides, salicifoliosides A (\n                    <jats:bold>1<\/jats:bold>\n                    ) and B (\n                    <jats:bold>2<\/jats:bold>\n                    ). Structurally, these compounds feature a rare structural motif consisting of an \u03b1,\u03b2\u2010unsaturated furanone aglycone esterified with a\n                    <jats:italic>p<\/jats:italic>\n                    \u2010coumaroyl unit, a combination scarcely reported in natural products. Spectroscopic and chemical analyses established that\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    are\n                    <jats:italic>cis\u2013trans<\/jats:italic>\n                    geometric isomers, offering a unique framework to investigate configuration\u2010dependent properties and expanding the structural diversity of furan glycosides. To evaluate their potential relevance to functional dyspepsia (FD), we adopted a prediction\u2011to\u2011validation strategy. Network pharmacology analysis and molecular docking identified matrix metalloproteinase\u20102 (MMP2) as a potential target. In a lipopolysaccharide (LPS)\u2010stimulated Caco\u20112 cell model, compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    significantly inhibited the secretion of MMP2 and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), consistent with the earlier in silico predictions. Notably, compound\n                    <jats:bold>1<\/jats:bold>\n                    also reduced interleukin\u20102 (IL\u20102) levels, suggesting a configuration\u2010dependent effect. This study highlights a previously unrecognized natural product scaffold and provides initial evidence linking its structure to anti\u2010inflammatory activity, offering new insights into structure\u2013activity relationship studies and drug discovery.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71564","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T19:19:09Z","timestamp":1786043949000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Salicifoliosides A and B: A Pair of Furan Glycoside Isomers From\n                    <i>Chimonanthus salicifolius<\/i>\n                    and Their Modulation of the Functions of Caco\u20102 Cells"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5407-1795","authenticated-orcid":false,"given":"Hui\u2010Zhen","family":"Yang","sequence":"first","affiliation":[{"name":"School of Chinese Pharmacy Beijing 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