{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:09:08Z","timestamp":1788858548746,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260831"],"award-info":[{"award-number":["82260831"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hainan Province","doi-asserted-by":"publisher","award":["225RC752"],"award-info":[{"award-number":["225RC752"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Four new cadinane\u2010type sesquiterpenoids, named fisscadinanes A\u2013D (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>4<\/jats:bold>\n                    ), together with four known biogenetically related cadinane\u2010type sesquiterpenoids (\n                    <jats:bold>5<\/jats:bold>\n                    \u2013\n                    <jats:bold>8<\/jats:bold>\n                    ) were isolated from the roots of\n                    <jats:italic>Fissistigma tientangense<\/jats:italic>\n                    . The structures of these sesquiterpenoids were determined by comprehensive spectroscopic analyses. Compound\n                    <jats:bold>1<\/jats:bold>\n                    is a 15\u2010norcadinane sesquiterpene containing one\n                    <jats:italic>p<\/jats:italic>\n                    \u2010\n                    <jats:italic>\u03c0<\/jats:italic>\n                    \u2013\n                    <jats:italic>\u03c0<\/jats:italic>\n                    \u2010system. Compounds\n                    <jats:bold>2<\/jats:bold>\n                    \u2010\n                    <jats:bold>4<\/jats:bold>\n                    are cadinane sesquiterpenes. The absolute configurations of compounds\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>4<\/jats:bold>\n                    were determined via ECD calculations. The inhibitory activities of fisscadinanes A\u2013D against the nitric oxide (NO) production induced by lipopolysaccharide (LPS) in mouse macrophage RAW 264.7 cells in vitro were evaluated. Compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>7<\/jats:bold>\n                    exhibited significant inhibitory activities, possessing the IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 8.27 \u00b1 0.09 and 14.66 \u00b1 0.08 \u00b5M. The positive control, quercetin, displayed an inhibitory activity against NO production with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 14.87 \u00b1 0.11 \u00b5M.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71568","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T19:58:29Z","timestamp":1785959909000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Four New Cadinane\u2010Type Sesquiterpenoids From the Roots of\n                    <i>Fissistigma tientangense<\/i>"],"prefix":"10.1002","volume":"23","author":[{"given":"Ting","family":"Zheng","sequence":"first","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education Hainan Normal University  Haikou Hainan China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province College of Chemistry and Chemical Engineering Hainan Normal University  Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010Ze","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education Hainan Normal University  Haikou Hainan China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province College of Chemistry and Chemical Engineering Hainan Normal University  Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng\u2010Tian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education Hainan Normal University  Haikou Hainan China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province College of Chemistry and Chemical Engineering Hainan Normal University  Haikou Hainan 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