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Sinapic acid is a plant\u2010derived phenolic compound with antifungal activity. Therefore, in this study, a collection of eleven sinapates (\n                    <jats:bold>1<\/jats:bold>\n                    \u2010\n                    <jats:bold>11<\/jats:bold>\n                    ) was prepared and the antifungal activity of these compounds was evaluated against\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    and\n                    <jats:italic>Candida tropicalis<\/jats:italic>\n                    . Compounds\n                    <jats:bold>4<\/jats:bold>\n                    ,\n                    <jats:bold>5<\/jats:bold>\n                    , and\n                    <jats:bold>8<\/jats:bold>\n                    showed good antifungal activity. Compound\n                    <jats:bold>4<\/jats:bold>\n                    presented minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values of 62.5 \u00b5g\/mL against\n                    <jats:italic>C. albicans<\/jats:italic>\n                    and 15.62 \u00b5g\/mL against\n                    <jats:italic>C. tropicalis<\/jats:italic>\n                    . Compound\n                    <jats:bold>5<\/jats:bold>\n                    showed MIC and MFC values of 7.81 \u00b5g\/mL against both strains, while compound\n                    <jats:bold>8<\/jats:bold>\n                    presented MIC and MFC values of 15.62 \u00b5g\/mL against\n                    <jats:italic>C. albicans<\/jats:italic>\n                    and 62.5 \u00b5g\/mL against\n                    <jats:italic>C. tropicalis<\/jats:italic>\n                    . The ratio MFC\/MIC&lt;4 showed that the compounds exerted a fungicidal effect. The ergosterol assay suggests that the mechanism of action occurs via the plasma membrane. The silico study, including ADMET predictions, suggested that most of the compounds have satisfactory pharmacokinetic and toxicological properties. Therefore, sinapates appear to be promising prototypes for the development of new anti\u2010\n                    <jats:italic>Candida<\/jats:italic>\n                    drug candidates.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71569","type":"journal-article","created":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T10:53:01Z","timestamp":1786272781000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthetic Sinapates: Antifungal, Molecular Docking, and ADMET Studies"],"prefix":"10.1002","volume":"23","author":[{"given":"Fernando Emanuel de Sousa","family":"Ferreira","sequence":"first","affiliation":[{"name":"Laboratory of Pharmaceutical Chemistry, Department of Pharmaceutical Sciences Federal University of Para\u00edba  Jo\u00e3o Pessoa Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremias Justo","family":"Em\u00eddio","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Chemistry, Department of Pharmaceutical Sciences Federal University of Para\u00edba  Jo\u00e3o Pessoa Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6340-7380","authenticated-orcid":false,"given":"\u00c9zio Raul Alves","family":"de S\u00e1","sequence":"additional","affiliation":[{"name":"LaPeSI\u2013Information Systems Research Laboratory, Department of Information, Environment, Health and Food Production Federal Institute of Piau\u00ed  Teresina, Piau\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0000-033X","authenticated-orcid":false,"given":"R\u00f4mulo Oliveira","family":"Barros","sequence":"additional","affiliation":[{"name":"LaPeSI\u2013Information Systems Research Laboratory, Department of Information, Environment, Health and Food Production Federal Institute of Piau\u00ed  Teresina, Piau\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Lima","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pharmacology and Cell Culture, Department of Clinical and Social Dentistry Federal University of Paraiba  Jo\u00e3o Pessoa Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2016-3344","authenticated-orcid":false,"given":"Ricardo Martins","family":"Ramos","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pharmacology and Cell Culture, Department of Clinical and Social Dentistry Federal University of Paraiba  Jo\u00e3o Pessoa Para\u00edba Brazil"},{"name":"LaBME\u2013Laboratory of Molecular Biology and Epidemiology, Federal Institute of Education Science and Technology of Piau\u0131\u0301\u2013Campus Teresina Central  Teresina, Piau\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7986-7376","authenticated-orcid":false,"given":"Ricardo Dias","family":"de Castro","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pharmacology and Cell Culture, Department of Clinical and Social Dentistry Federal University of Paraiba  Jo\u00e3o Pessoa Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7180-4896","authenticated-orcid":false,"given":"Dami\u00e3o Pergentino","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Chemistry, Department of Pharmaceutical Sciences Federal University of Para\u00edba  Jo\u00e3o Pessoa Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01927"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jam.14949"},{"issue":"1","key":"e_1_2_11_4_1","first-page":"193","article-title":"Antifungal Activity of Lemon Balm (Lippia alba) Against the Fungus Candida Albicans: An Integrative Review","volume":"7","author":"DA Silva J. 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