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GC\/MS analysis of BcH identified heptacosane (30.89%), 3\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010myristoylolean\u201012\u2010en\u201016\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010ol (7.88%), and spathulenol (5.8%) as major components. UPLC\u2013MS analysis showed distinct profiles for BcD and BcM extracts; BcD was characterized by flavonoids such as cirsimaritin, acacetin, and pectolinaringenin, while BcM contained chlorogenic acids (5\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010caffeoylquinic acid, 1\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010caffeoylquinic acid, 3,4\u2010di\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010caffeoylquinic acid, and 4,5\u2010di\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010caffeoylquinic acid), and flavonoids (vicenin\u20102 and rutin). In vivo, oral administration of all extracts (100\u00a0mg\/kg) reduced paw edema, with BcD and BcM significantly decreasing paw swelling from 3\u00a0h onward, with effects comparable to those of the reference drug meloxicam (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05), while BcH showed lower activity. In vitro, the effects of the extracts were assessed using SEAP reporter activity as an indicator of NF\u2010\u03baB\/AP\u20101 signaling. BcD and BcM significantly reduced SEAP activity in a concentration\u2010dependent manner, whereas BcH showed a lower inhibitory effect. Overall, extracts of\n                    <jats:italic>B. conferta<\/jats:italic>\n                    exert anti\u2010inflammatory activity by modulating NF\u2010\u03baB\/AP\u20101 signaling. These findings support the potential of\n                    <jats:italic>B. conferta<\/jats:italic>\n                    as a promising candidate for treating inflammatory diseases.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71570","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T17:21:05Z","timestamp":1786209665000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extracts of\n                    <i>Baccharis conferta<\/i>\n                    Kunth Reduce Carrageenan\u2010Induced Paw Edema in Mice and Inhibit NF\u2010\n                    <i>\u03ba<\/i>\n                    B in LPS\u2010Stimulated RAW\u2010Blue Macrophages"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6566-1120","authenticated-orcid":false,"given":"Ana Silvia","family":"Guti\u00e9rrez\u2010Rom\u00e1n","sequence":"first","affiliation":[{"name":"Centro de Desarrollo de Productos Bi\u00f3ticos Instituto Polit\u00e9cnico Nacional  Yautepec Morelos M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maribel","family":"Herrera\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur Instituto Mexicano del Seguro Social  Xochitepec Morelos M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3693-1670","authenticated-orcid":false,"given":"Manases","family":"Gonz\u00e1lez\u2010Cortazar","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur Instituto Mexicano del Seguro Social  Xochitepec Morelos M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0783-8274","authenticated-orcid":false,"given":"Enrique","family":"Jim\u00e9nez\u2010Ferrer","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur Instituto Mexicano del Seguro Social  Xochitepec Morelos M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7479-9332","authenticated-orcid":false,"given":"Gabriela","family":"Trejo\u2010Tapia","sequence":"additional","affiliation":[{"name":"Centro de Desarrollo de Productos Bi\u00f3ticos Instituto Polit\u00e9cnico Nacional  Yautepec Morelos M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109347"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07201"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153309"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.08.094"},{"key":"e_1_2_9_6_1","first-page":"1099","article-title":"TLR4\/MyD88\u2010Dependent, LPS\u2010Induced Synthesis of prostaglandin E2","volume":"16","author":"Weinlich R.","year":"2009","journal-title":"Cell Death and Differentiation"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13061323"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02408-13"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23208"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sigtrans.2017.23"},{"key":"e_1_2_9_11_1","volume-title":"Atlas de las plantas de la medicina tradicional mexicana","author":"Argueta\u2010Villamar A.","year":"1994"},{"key":"e_1_2_9_12_1","first-page":"61","article-title":"Herbolaria Mexicana para el Tratamiento del Dolor","volume":"66","author":"Mart\u00ednez A. 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