{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:09:14Z","timestamp":1788858554031,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The whole plant of\n                    <jats:italic>Astragalus rigidulus<\/jats:italic>\n                    Benth. ex Bunge (Fabaceae) has been employed in Tibet to clear lung heat, alleviate diarrhea and edema. In the present study, a phytochemical investigation of\n                    <jats:italic>A. rigidulus<\/jats:italic>\n                    led to the isolation of a new alkaloid,\n                    <jats:italic>n<\/jats:italic>\n                    \u2010butyl hematinate (\n                    <jats:bold>1<\/jats:bold>\n                    ), and a new benzyl ester, astrigioside A (\n                    <jats:bold>2<\/jats:bold>\n                    ), along with twenty known analogs (\n                    <jats:bold>3\u201322<\/jats:bold>\n                    ). Their structures were elucidated through comprehensive spectroscopic analysis, including 1D\/2D NMR, UV, IR, HR\u2010ESI\u2010MS, and comparison of the spectroscopic data with those reported in literatures. The UT\u2010B inhibitory activities of all isolates were evaluated by erythrocyte lysis assay model. As a result, compounds\n                    <jats:bold>7<\/jats:bold>\n                    ,\n                    <jats:bold>8<\/jats:bold>\n                    ,\n                    <jats:bold>10<\/jats:bold>\n                    , and\n                    <jats:bold>18<\/jats:bold>\n                    possessed significant UT\u2010B inhibitory effects, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 22.93 \u00b1 0.88, 26.40 \u00b1 0.73, 21.83 \u00b1 0.68, 29.60 \u00b1 0.75\u00a0\u00b5M, respectively.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71571","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T19:38:44Z","timestamp":1785958724000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemical Constituents with UT\u2010B Inhibitory Activity from\n                    <i>Astragalus rigidulus<\/i>"],"prefix":"10.1002","volume":"23","author":[{"given":"Jing","family":"Wu","sequence":"first","affiliation":[{"name":"Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine Jiangxi University of Chinese Medicine  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Wen","sequence":"additional","affiliation":[{"name":"Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine Jiangxi University of Chinese Medicine  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine Jiangxi University of Chinese Medicine  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine Jiangxi University of Chinese Medicine  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4215-681X","authenticated-orcid":false,"given":"Gang","family":"Ren","sequence":"additional","affiliation":[{"name":"Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine Jiangxi University of Chinese Medicine  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"318","article-title":"Research Progress on Thiazide Diuretics in the Treatment of Hypertension","volume":"4","author":"Wu M.","year":"2019","journal-title":"Chinese Journal of Hypertension"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000164149"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.06.034"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424\u2010003\u20101124\u2010x"},{"key":"e_1_2_9_6_1","first-page":"937","article-title":"Research Prgoress in Urea Transporters as a Novel Diuretic Target","volume":"12","author":"Zhang S.","year":"2020","journal-title":"Chinese Journal of Pharmacology and Toxicology"},{"key":"e_1_2_9_7_1","volume-title":"Flora of China","author":"Editorial Committee of Flora of China","year":"1993"},{"key":"e_1_2_9_8_1","volume-title":"Tibetan Medicine","author":"Yang Y. 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