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Cytotoxicity was assessed in murine peritoneal macrophages, and the mechanism of action was investigated in\n                    <jats:italic>L. (L.) infantum<\/jats:italic>\n                    promastigotes by evaluating mitochondrial membrane potential (\u0394\n                    <jats:italic>\u03a8<\/jats:italic>\n                    m), reactive oxygen species (ROS) production, and plasma membrane integrity. Dicentrine exhibited potent activity against promastigote and intracellular amastigote forms, with EC\n                    <jats:sub>50<\/jats:sub>\n                    values ranging from 0.86 to 1.64 \u00b5g\/mL. The compound showed low cytotoxicity toward macrophages (CC\n                    <jats:sub>50<\/jats:sub>\n                    = 162.5 \u00b5g\/mL), resulting in high selectivity indices (up to 188.3). Mechanistic studies revealed significant disruption of \u0394\n                    <jats:italic>\u03a8<\/jats:italic>\n                    m and a dose\u2010dependent increase in ROS production, indicating mitochondrial dysfunction and oxidative stress as key events in parasite death. These findings highlight dicentrine as a promising lead for antileishmanial drug development.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71575","type":"journal-article","created":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T16:37:33Z","timestamp":1786293453000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dicentrine, an Aporphine Alkaloid From\n                    <i>Ocotea langsdorffii<\/i>\n                    , Induces Mitochondrial Dysfunction and Oxidative Stress in\n                    <i>Leishmania (L.) infantum<\/i>"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7882-215X","authenticated-orcid":false,"given":"Camila S.","family":"de Freitas","sequence":"first","affiliation":[{"name":"Post\u2010graduation Program in Health Sciences \u2010 Infectiology and Tropical Medicine, Medicine Faculty Federal University of Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8483-1218","authenticated-orcid":false,"given":"Eduardo Oliveira S.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Center of Natural Sciences and Humanities Federal University of the ABC  Santo Andre Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2656-7454","authenticated-orcid":false,"given":"Daniela C.","family":"Trist\u00e3o","sequence":"additional","affiliation":[{"name":"Center of Natural Sciences and Humanities Federal University of the ABC  Santo Andre Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8109-4544","authenticated-orcid":false,"given":"Guilherme M.","family":"Antar","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Biological Sciences Federal University of Espirito Santo  S\u00e3o Matheus Espirito Santo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela P.","family":"Lage","sequence":"additional","affiliation":[{"name":"Post\u2010graduation Program in Health Sciences \u2010 Infectiology and Tropical Medicine, Medicine Faculty Federal University of Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00f3ris M.","family":"Abr\u00e3o","sequence":"additional","affiliation":[{"name":"Post\u2010graduation Program in Health Sciences \u2010 Infectiology and Tropical Medicine, Medicine Faculty Federal University of Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5183-1141","authenticated-orcid":false,"given":"Luciana M. Ribeiro","family":"Antinarelli","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Microbiology and Immunology, Institute of Biological Sciences Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1005-278X","authenticated-orcid":false,"given":"Elaine S.","family":"Coimbra","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Microbiology and Immunology, Institute of Biological Sciences Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Henrique G.","family":"Lago","sequence":"additional","affiliation":[{"name":"Center of Natural Sciences and Humanities Federal University of the ABC  Santo Andre Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6681-9014","authenticated-orcid":false,"given":"Eduardo A. 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