{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:09:13Z","timestamp":1788858553380,"version":"build-2803163510"},"reference-count":110,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Natural remedies combined with bioinformatics accelerate the formulation of safer, targeted drugs. This study provides a comprehensive description of the phytochemical and pharmacological aspects of\n                    <jats:italic>Silene colorata<\/jats:italic>\n                    . Binding profiles of eight identified compounds were simulated against \u03b1\u2010amylase. GC\u2010MS analysis revealed 57 compounds, mainly fatty acids and esters (73.65%), while UHPLC\u2013MS\/MS identified 2\u2032,4\u2032\u2010dihydroxychalcone (20.72%), (\n                    <jats:italic>epi<\/jats:italic>\n                    )gallocatechin\u2010\n                    <jats:italic>C<\/jats:italic>\n                    \u2010hexoside (12.53%), apigetrin (10.10%), and hexahydroxyheptanoic acid (8.57%) as major components. The hydro\u2010alcoholic extract showed a strong antiradical effect (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a07.57\u00a0\u00b1\u00a00.26\u00a0\u00b5g\/mL by ABTS assay; A\n                    <jats:sub>0.50<\/jats:sub>\n                    \u00a0=\u00a048.93\u00a0\u00b1\u00a03.88\u00a0\u00b5g\/mL by phenanthroline assay). Its sun protection factor (SPF) was also the highest (40.561\u00a0\u00b1\u00a00.87). The chloroform fraction showed notable activity against \u03b1\u2010amylase (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a022.86\u00a0\u00b1\u00a03.19\u00a0\u00b5g\/mL) and butyrylcholinesterase (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a0111.08\u00a0\u00b1\u00a04.72\u00a0\u00b5g\/mL). The complex 3\u2010tetradecyn\u20101\u2010ol and \u03b1\u2010amylase appeared more stable, but in an antagonistic manner (\u22124.8\u00a0kcal\/mol). While this work reveals crucial findings, further in vivo studies are needed to confirm and expand on these results.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71578","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T19:32:45Z","timestamp":1785958365000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["GC\u2010Ms, UHPLC\u2013MS\/MS\n                    <sup>n<\/sup>\n                    Phytoconstituents Characterization and Physio\u2010pharmacological Investigation of\n                    <i>Silene colorata<\/i>\n                    subsp\n                    <i>. amphorina<\/i>\n                    (Pomel) Batt. From Northeastern Algeria"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1171-2797","authenticated-orcid":false,"given":"Mohamed Sabri","family":"Bensaad","sequence":"first","affiliation":[{"name":"Faculty of Natural and Life Sciences University Batna 2  Batna Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1400-0541","authenticated-orcid":false,"given":"Zina","family":"Allaoua","sequence":"additional","affiliation":[{"name":"Laboratory of Chemistry and Environmental Chemistry (L.C.C.E), Faculty of Matter Sciences Department of Chemistry  Batna Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5112-0481","authenticated-orcid":false,"given":"Mohamed Amine","family":"Kahoul","sequence":"additional","affiliation":[{"name":"Laboratory of Food Sciences (LSA) Institute of Veterinary Sciences and Agronomic Sciences  Batna Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4249-7089","authenticated-orcid":false,"given":"Diana C. G. A.","family":"Pinto","sequence":"additional","affiliation":[{"name":"LAQV\/REQUIMTE, Department of Chemistry, Campus Universit\u00e1rio de Santiago University of Aveiro  Aveiro Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chawki","family":"Bensouici","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center Ali Mendjli UV 03  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4999-5673","authenticated-orcid":false,"given":"Salah","family":"Akkal","sequence":"additional","affiliation":[{"name":"Valorization of Natural Resources, Bioactive Molecules and Biological Analysis Unit, Department of Chemistry Fr\u00e8res Mentouri Constantine 1 University  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healthpol.2026.105580"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.20906"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14060555"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-025-10194-7"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imr.2015.06.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3RA01793A"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3897\/phytokeys.227.100850"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29204817"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2018.10.005"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.26502\/ijpaes.4490170"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S538326"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2025.2004"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-04430-y"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.15466"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105416"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2014.980251"},{"key":"e_1_2_9_18_1","first-page":"393","article-title":"Real\u2010World Application of Molecular Docking in Drug Discovery","volume":"103","author":"Dutta S.","year":"2025","journal-title":"Advances in Pharmacological and Pharmaceutical Sciences"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-02773-7"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2023.104619"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.10049"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/d6030415"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14101285"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-025-01314-x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.c24-00809"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202100664"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf506076n"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/bms138"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.7202"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants13060909"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60076-5"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27072314"},{"key":"e_1_2_9_33_1","first-page":"17","article-title":"UPLC\u2010ESI\u2010MS\/MS Profile and Antioxidant, Cytotoxic, Antidiabetic, and Antiobesity Activities of the Aqueous Extracts of Three Different Hibiscus Species","volume":"6749176","author":"Al\u2010Yousef H. 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