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Their structures were established by HRESIMS, NMR, and ECD analyses. All isolates were evaluated for neuroprotective effects against 6\u2010hydroxydopamine\u2010induced injury in PC12 cells. Compounds\n                    <jats:bold>2<\/jats:bold>\n                    and\n                    <jats:bold>10<\/jats:bold>\n                    showed the most potent activities, increasing cell viability by 20.54% and 30.67%, respectively, at 50\u00a0\u00b5M. Mechanistic studies indicated that both compounds reduced intracellular ROS accumulation and enhanced SOD activity, while compound\n                    <jats:bold>10<\/jats:bold>\n                    further activated the Nrf2\/HO\u20101 signaling pathway. These findings suggest that dibenzocyclooctadiene lignans from\n                    <jats:italic>K. coccinea<\/jats:italic>\n                    are promising neuroprotective agents against oxidative stress\u2010induced neuronal injury.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71579","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T20:05:26Z","timestamp":1785960326000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Six Undescribed Dibenzocyclooctadiene Lignans With Neuroprotective Effects From\n                    <i>Kadsura coccinea<\/i>\n                    Roots"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5242-0180","authenticated-orcid":false,"given":"An","family":"Jin","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Hunan University of Medicine  Huaihua China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7313-9907","authenticated-orcid":false,"given":"Gang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Hunan University of Medicine  Huaihua China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiong","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Hunan University of Medicine  Huaihua China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfei","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Jiangxi Provincial People's Hospital The First Affiliated Hospital of Nanchang Medical College  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6164-5393","authenticated-orcid":false,"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Jiangxi Provincial People's Hospital The First Affiliated Hospital of Nanchang Medical College  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8770-6861","authenticated-orcid":false,"given":"Wenming","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Jiangxi Provincial People's Hospital The First Affiliated Hospital of Nanchang Medical College  Nanchang China"},{"name":"Jiangxi Provincial Education Department Key Laboratory for the Application of Key Technologies in Drug Screening For Inflammatory Diseases and Phlegm Syndrome  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106872"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2025.106415"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114759"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chmed.2020.03.006"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2014.01.015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2021.113018"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2021.112678"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13659\u2010023\u201000376\u20101"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105277"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.119335"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156612"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.10.048"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.04.040"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2025.2479247"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2024.106184"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2026.114780"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118472"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.05.015"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2025.109120"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.5935\/0103\u20105053.20130253"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031\u20109422(92)90049\u2010v"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/np1009288"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo9622542"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031\u20109422(95)00043\u20107"}],"container-title":["Chemistry &amp; 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