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This review provides a comprehensive synthesis of current knowledge on the phytochemistry and pharmacological activities of\n                    <jats:italic>Saurauia<\/jats:italic>\n                    species, with emphasis on isolated secondary metabolites and extract\u2010based bioactivity studies. To date, 61 compounds have been reported from the genus, predominantly pentacyclic triterpenoids, flavonoids, phenolic compounds, sterols, and glycosidic derivatives. Pharmacological investigations have demonstrated a broad spectrum of biological activities, including antidiabetic, antihyperlipidemic, antioxidant, antimicrobial, anti\u2010inflammatory, cytotoxic, immunomodulatory, wound\u2010healing, hepatoprotective, and chemopreventive effects. Among the studied species,\n                    <jats:italic>S. vulcani<\/jats:italic>\n                    exhibited the most diverse pharmacological profile, particularly in antidiabetic, antioxidant, wound\u2010healing, antihyperlipidemic, and immunomodulatory models, whereas\n                    <jats:italic>S. roxburghii<\/jats:italic>\n                    showed notable antioxidant, neuropharmacological, analgesic, thrombolytic, and cytotoxic activities. Chemotaxonomic evidence suggests that triterpenoids and flavonoids represent characteristic metabolites within the genus and may contribute significantly to its biological potential. Despite these promising findings, research remains largely extract\u2010based, with limited compound isolation, mechanistic studies, toxicity evaluation, and clinical validation.\n                    <jats:italic>Saurauia<\/jats:italic>\n                    represents a chemically rich yet underexplored genus with significant potential for future drug discovery targeting chronic and degenerative diseases.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71580","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:00:17Z","timestamp":1787680817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Comprehensive Review of the Phytochemistry and Pharmacological Potential of the Genus\n                    <i>Saurauia<\/i>\n                    (Actinidiaceae)"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2339-5941","authenticated-orcid":false,"given":"Areej","family":"Fatima","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4724-3256","authenticated-orcid":false,"given":"Denny","family":"Satria","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biology Faculty of Pharmacy Universitas Sumatera Utara  Medan Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9891-5898","authenticated-orcid":false,"given":"Yeun\u2010Mun","family":"Choo","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.7751\/telopea15453"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/boj.12382"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.36253\/jopt\u201013193"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.3724\/SP.J.1143.2008.07113"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.37934\/spnes.2.1.1215a"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.23960\/jsl.v13i2.1139"},{"key":"e_1_2_15_8_1","first-page":"103","article-title":"Jenis\u2010jenis Tumbuhan Hutan Asli Kalimantan Yang Berpotensi Sebagai Sumber Pangan di Kabupaten Malinau Dan Berau Kalimantan Timur","volume":"1","author":"Sidiasa K.","year":"2011","journal-title":"Prosiding Seminar Hasil\u2010Hasil Penelitian BPTKSDA Samboja"},{"key":"e_1_2_15_9_1","first-page":"641","article-title":"The Phenolic Components from Saurauia napaulensis","volume":"20","author":"Qiong W.","year":"2008","journal-title":"Natural Product Research & Development"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prmcm.2023.100336"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13002\u2010022\u201000501\u20103"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13002\u2010015\u20100019\u20101"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.5530\/pj.2020.12.97"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2025.100792"},{"issue":"4","key":"e_1_2_15_15_1","first-page":"1825","article-title":"Phytochemical and Biological Investigations of Saurauja roxburghii","volume":"24","author":"Chowdhury M. 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