{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:09:25Z","timestamp":1788858565395,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The ethnomedicinal relevance of\n                    <jats:italic>Hypericum orientale<\/jats:italic>\n                    L. suggests notable pharmacological potential; however, its organ\u2010specific phytochemical composition and biological activities remain insufficiently characterized. This study investigated the phytochemical profiles, cytoprotective activity, and antimicrobial properties of methanolic extracts obtained from the aerial parts and roots of\n                    <jats:italic>H. orientale<\/jats:italic>\n                    . Phytochemical analyses revealed distinct organ\u2010dependent profiles. Hyperoside was the major constituent in both extracts, while the aerial extract was particularly rich in flavonols and flavones, including hyperoside, myricetin, acacetin, and quercetin. In contrast, the root extract was characterized by higher levels of catechin\u2010type phenolics, especially (\u2212)\u2010epicatechin and (+)\u2010catechin. Hypericin, pseudohypericin, and hyperforin were not detected. The main contribution of this study is the integrated evaluation of organ\u2010specific phytochemical variation together with respiratory\u2010relevant cytoprotective and antimicrobial screening. In a cigarette smoke extract\u2010induced bronchial cytotoxicity model, 10% cigarette smoke extract reduced BEAS\u20102B cell viability to 38.32% \u00b1 2.46%, whereas pre\u2010treatment with the aerial extract significantly attenuated this cytotoxicity. Antimicrobial evaluation showed notable activity against ATCC reference strains (MIC = 7.8 \u00b5g\/mL); however, efficacy was markedly reduced against multidrug\u2010resistant clinical isolates (MIC &gt; 250 \u00b5g\/mL), limiting direct antimicrobial relevance. Overall,\n                    <jats:italic>H. orientale<\/jats:italic>\n                    appears to be a promising source of phenolic constituents with cytoprotective potential.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71582","type":"journal-article","created":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T16:43:03Z","timestamp":1786293783000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective Effects of\n                    <i>Hypericum orientale<\/i>\n                    L. Extracts Against Cigarette Smoke\u2010Induced Bronchial Cytotoxicity and Respiratory Pathogens"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7617-1701","authenticated-orcid":false,"given":"Nurdan","family":"Yazici","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmacognosy Karadeniz Technical University  Trabzon T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3617-020X","authenticated-orcid":false,"given":"\u00d6mer\u00fcl Faruk","family":"Tavli","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmacognosy Biruni University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1569-2535","authenticated-orcid":false,"given":"Esra","family":"Ero\u011flu \u00d6zkan","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of 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