{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:09:19Z","timestamp":1788858559726,"version":"build-2803163510"},"reference-count":93,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The chemical composition and biological activities of\n                    <jats:italic>Malus domestica<\/jats:italic>\n                    \u2018Ak Sak\u0131\u2019 fruits cultivated in Erzincan, T\u00fcrkiye, were analyzed. The aroma profile of the fruits was investigated for the first time. This study aimed to identify the major volatile and phenolic compounds and determine their antioxidant, antimicrobial, and cytotoxicity properties to investigate the potential health benefits of this cultivar. GC\u2010MS analysis identified major volatile compounds, including 1\u2010hexanol (20.54%), benzaldehyde (13.49%), and 1\u2010octanol (6.68%). LC\u2010MS\/MS analysis of phenolic compounds in the ethyl acetate fraction revealed high levels of chlorogenic acid (12\u00a0802.67\u00a0\u00b5g\/g), catechin (8601.52\u00a0\u00b5g\/g), and quercetin (805.96\u00a0\u00b5g\/g). Among the tested extracts, the ethyl acetate extract exhibited the highest antioxidant activity (47.18 \u00b1 0.92\u00a0\u00b5g\/mL), total phenolic content (70.17 \u00b1 0.28\u00a0mg GAE\/g extract), and reducing power (90.17 \u00b1 0.71\u00a0mg TE\/g extract), followed by butanol and diethyl ether extracts. Antimicrobial tests demonstrated varying inhibition zones, with volatile oil being the most effective. In addition, extracts exhibit cytotoxicity potential. The diethyl ether fraction shows the most potent selective cytotoxicity against A549 lung cancer cells. The findings indicate that the \u2018Ak Saki\u2019 cultivar contains diverse bioactive compounds with strong antioxidant, cytotoxicity, and antimicrobial properties. This fruit may contribute to the nutritional and health value of the daily diet.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71587","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T17:23:07Z","timestamp":1786209787000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemical Composition and Biological Activities of\n                    <i>Malus domestica<\/i>\n                    Burkh. \u2018Ak Sak\u0131\u2019 Cultivar Growing in Erzincan"],"prefix":"10.1002","volume":"23","author":[{"given":"H\u00fcseyin","family":"Ak\u015fit","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Department of Analytical Chemistry Erzincan Binali Y\u0131ld\u0131r\u0131m University  Erzincan T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emircan","family":"Aydemir","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Department of 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