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Four derivatives (\n                    <jats:bold>24a<\/jats:bold>\n                    \u2212\n                    <jats:bold>24d<\/jats:bold>\n                    ) were also obtained through structural optimization. Their structures were elucidated by a combination of spectroscopic data, chemical methods, and x\u2010ray diffraction. Cytotoxicity screening indicated that\n                    <jats:bold>24c<\/jats:bold>\n                    , an oxime ester derivative of\n                    <jats:bold>24<\/jats:bold>\n                    , exerted the most potent activity against the non\u2010small\u2010cell lung cancer (NSCLC) cell line H1975, with higher potency than the positive control cisplatin. Mechanism study revealed that\n                    <jats:bold>24c<\/jats:bold>\n                    could promote cell\u2010cycle arrest in S phase and induce cell apoptosis.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71589","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T17:26:32Z","timestamp":1786209992000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abietane\u2010Type Diterpenoids From\n                    <i>Salvia kiangsiensis<\/i>\n                    : Isolation, Semisynthesis, and Cytotoxicity of Their Oxime Ester Derivatives"],"prefix":"10.1002","volume":"23","author":[{"given":"Wei\u2010Ye","family":"Wu","sequence":"first","affiliation":[{"name":"Key Lab of Natural Product Chemistry and Application at Universities of Education Department of Xinjiang Uygur Autonomous Region, School of Chemistry and Chemical Engineering Yili Normal University  Yining China"},{"name":"School of Pharmaceutical Sciences Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei\u2010Ming","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Gan","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Qi","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4404-6348","authenticated-orcid":false,"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Lab of Natural Product Chemistry and Application at Universities of Education Department of Xinjiang Uygur Autonomous Region, School of Chemistry and Chemical Engineering Yili Normal University  Yining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5678-6634","authenticated-orcid":false,"given":"Sheng","family":"Yin","sequence":"additional","affiliation":[{"name":"Key Lab of Natural Product Chemistry and Application at Universities of Education Department of Xinjiang Uygur Autonomous Region, School of Chemistry and Chemical Engineering Yili Normal University  Yining China"},{"name":"School of Pharmaceutical Sciences Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00798-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000663"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25183"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.21037\/tcr-23-1816"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01029-8"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.84"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01740-y"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr900019j"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2019.112064"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NP00047D"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2021.03.030"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-024-10060-y"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600-018-2418-8"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-025-02040-w"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(89)85033-2"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)81178-4"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)87965-5"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(83)80033-8"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/np010032f"},{"key":"e_1_2_9_22_1","first-page":"96","article-title":"Constituents of Hinokiol. 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