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Untargeted metabolomics identified 94 compounds and 12 differential metabolites, with anthraquinones abundant in roots and flavonoids dominant in stems. Combined with network pharmacology and molecular docking, key active ingredients were found to target TNF\u2010\u03b1, IL\u20106 and other core genes via the PI3K\u2010Akt pathway. Except for lyoniresinol, most active compounds exhibited good target binding activity. LPS\u2010induced mouse experiments further validated the herb's efficacy in lowering fever and suppressing pro\u2010inflammatory cytokines. 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Hengsheng Pharmaceutical Co., Ltd  Zhongshan China"},{"name":"Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1008\u20100805.2008.04.023"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.13210\/j.cnki.jhmu.20230406.001"},{"key":"e_1_2_10_4_1","unstructured":"X.Chen \u201cResearch on the Anti\u2011Tumor Effect ofBerchemia lineata \u201d South\u2010Central Minzu University 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