{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:09:01Z","timestamp":1788858541740,"version":"build-2803163510"},"reference-count":111,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Crateva religiosa<\/jats:italic>\n                    G. Forst. is a highly valued medicinal plant in Ayurvedic tradition\u00a0and has been extensively investigated for its botanical characteristics, phytochemical composition, and diverse pharmacological properties. Related taxa within the genus such as\n                    <jats:italic>C. nurvala<\/jats:italic>\n                    and\n                    <jats:italic>C. magna<\/jats:italic>\n                    , along with allied species including\n                    <jats:italic>C. adansonii<\/jats:italic>\n                    and\n                    <jats:italic>C. tapia<\/jats:italic>\n                    , are frequently discussed alongside\n                    <jats:italic>C. religiosa<\/jats:italic>\n                    because of their shared ethnomedicinal applications and overlapping chemical classes. The genus exhibits promising effects in managing urolithiasis, cancer, inflammatory and neurodegenerative disorders, hepatic and renal dysfunctions, as well as microbial infections, supported by a rich array of secondary metabolites, including flavonoids, phenolic acids, alkaloids, phytosterols, and triterpenoids. While lupeol is consistently emphasized across different\n                    <jats:italic>Crateva<\/jats:italic>\n                    species, several studies have also attributed the key pharmacological effects of the genus to flavonoids and phenolics, suggesting a broader chemical basis for its therapeutic benefits. Integrating data from allied taxa strengthens the review by highlighting cross\u2010species consistency in phytochemistry and biological relevance, thereby supporting a unified genus\u2010level perspective. Furthermore, the advances in tissue culture techniques have facilitated efficient micropropagation and conservation of\n                    <jats:italic>Crateva<\/jats:italic>\n                    species, thus providing a valuable foundation for future biological investigations. This review bridges traditional knowledge with modern pharmacological evidence for\n                    <jats:italic>C. religiosa<\/jats:italic>\n                    and its relatives and highlights the need for deeper mechanistic, clinical, and metabolomic studies to fully validate their medicinal potential.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71597","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:00:31Z","timestamp":1786719631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Crateva religiosa<\/i>\n                    and Allied Species in Traditional Knowledge and Modern Pharmacology: A Review"],"prefix":"10.1002","volume":"23","author":[{"given":"Rania T.","family":"Saleh","sequence":"first","affiliation":[{"name":"Postgraduate Program in Pharmacognosy department Faculty of Pharmacy Cairo University  Cairo Egypt"},{"name":"Food Science Department National Nutrition Institute (NNI)  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6823-1142","authenticated-orcid":false,"given":"Seham S.","family":"Elhawary","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department Faculty of Pharmacy Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar A.","family":"Khairy","sequence":"additional","affiliation":[{"name":"Clinical Nutrition Department National Nutrition Institute (NNI)  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5706-9607","authenticated-orcid":false,"given":"Sherif A.","family":"Hamdy","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department Faculty of Pharmacy Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b01285"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0041\u20100101(00)00154\u20109"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30183705"},{"issue":"1","key":"e_1_2_11_5_1","first-page":"11","article-title":"A Scientific Review on Crateva religiosa","volume":"7","author":"Srinivas V.","year":"2018","journal-title":"International journal of advances in pharmacy biology and chemistry"},{"issue":"7","key":"e_1_2_11_6_1","first-page":"5822","article-title":"A Systematic Review of Crateva Species for It's Traditional and Modern Medicinal Uses","volume":"12","author":"Thomas J.","year":"2023","journal-title":"California Bulletin"},{"key":"e_1_2_11_7_1","first-page":"111","article-title":"Major Herbs of Ayurveda","author":"Williamson E.","year":"2002","journal-title":"Journal of Elsevier Science Limited"},{"issue":"1","key":"e_1_2_11_8_1","first-page":"923","article-title":"Medicinal Profile of a Scared Drug in Ayurveda: Crataeva religiosa a Review","volume":"3","author":"Patil U. 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