{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:58:40Z","timestamp":1790542720241,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Dietary strategies focused on reducing sodium intake and increasing plant\u2010based foods rich in bioactive compounds are increasingly recognized for preventing metabolic disorders. In this context, herbs and spices are valuable functional ingredients with sensory and health\u2010promoting properties.\n                    <jats:italic>Rhus coriaria<\/jats:italic>\n                    L. (sumac), a traditional Mediterranean spice appreciated for its sour taste and rich phenolic profile, remains only partially characterized biologically. This study investigated the phenolic composition and biological activities of the aqueous extract of Sicilian sumac using chemical, enzymatic, and cell\u2010based assays. HPLC\u2010PDA\/ESI\u2010MS analysis revealed a profile dominated by gallic acid derivatives, with gallic acid (46.45\u00a0mg\/g dried extract) and galloyl malic acid (7.16\u00a0mg\/g) as the major constituents, alongside minor amounts of protocatechuic acid and the flavonol glycosides myricetin and quercetin rhamnoside. Antioxidant activity was evaluated by DPPH and ABTS assays, while antidiabetic potential was assessed through \u03b1\u2010amylase and \u03b1\u2010glucosidase inhibition compared with acarbose (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 2.2\u00a0mg\/mL and 0.04\u00a0mg\/mL, respectively). Antiglycation activity was assessed using the BSA\u2013methylglyoxal model, and cytoprotective effects were evaluated in H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010stimulated HepG2 cells. The extract exhibited antioxidant, enzyme inhibitory, antiglycation, and ROS\u2010reducing activities, supporting further investigation as a functional ingredient, while emphasizing that in vivo studies are required to confirm its biological efficacy.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71600","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:15:25Z","timestamp":1788200125000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Traditional Spice to Functional Ingredient: Phenolic Profile and Bioactive Properties of Sicilian\n                    <i>Rhus coriaria<\/i>\n                    L. Fruit"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6441-1461","authenticated-orcid":false,"given":"Katia","family":"Arena","sequence":"first","affiliation":[{"name":"Messina Institute of Technology c\/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences University of Messina Viale G. Palatucci 13 Messina 98168 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7499-3944","authenticated-orcid":false,"given":"Donatella","family":"Ambroselli","sequence":"additional","affiliation":[{"name":"Department of Science and Bio\u2010Technology Universit\u00e0 Campus Bio\u2010Medico Di Roma Via Alvaro del Portillo 21 Roma 00128 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0748-1789","authenticated-orcid":false,"given":"Roberto","family":"Lagan\u00e0 Vinci","sequence":"additional","affiliation":[{"name":"Chromaleont s.r.l., C\/O Department of Chemical, Biological, Pharmaceutical and Environmental Sciences University of Messina Viale G. Palatucci 13 Messina 98168 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8890-675X","authenticated-orcid":false,"given":"Luigi","family":"Mondello","sequence":"additional","affiliation":[{"name":"Messina Institute of Technology c\/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences University of Messina Viale G. Palatucci 13 Messina 98168 Italy"},{"name":"Chromaleont s.r.l., C\/O Department of Chemical, Biological, Pharmaceutical and Environmental Sciences University of Messina Viale G. Palatucci 13 Messina 98168 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Santi","sequence":"additional","affiliation":[{"name":"Department of Environmental Biology Sapienza University of Rome Piazzale Aldo Moro 5 Rome 00185 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5527-0364","authenticated-orcid":false,"given":"Laura","family":"Dugo","sequence":"additional","affiliation":[{"name":"Department of Science and Bio\u2010Technology Universit\u00e0 Campus Bio\u2010Medico Di Roma Via Alvaro del Portillo 21 Roma 00128 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Dugo","sequence":"additional","affiliation":[{"name":"Messina Institute of Technology c\/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences University of Messina Viale G. Palatucci 13 Messina 98168 Italy"},{"name":"Chromaleont s.r.l., C\/O Department of Chemical, Biological, Pharmaceutical and Environmental Sciences University of Messina Viale G. Palatucci 13 Messina 98168 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.018585"},{"key":"e_1_2_9_3_1","volume-title":"Sodium Intake for Adults and Children","author":"World Health 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