{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:09:06Z","timestamp":1788858546672,"version":"build-2803163510"},"reference-count":74,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Thymus daenensis<\/jats:italic>\n                    is a pharmacologically important species, as its monoterpene\u2010rich essential oil exhibits strong antibacterial activity. This study examined the developmental regulation of bioactive compounds in\n                    <jats:italic>T. daenensis<\/jats:italic>\n                    during two key vegetative growth stages: an early stage (4 weeks post\u2010germination, WPG) and a late stage (8 WPG), under controlled laboratory conditions. Using an integrated analytical approach, we quantified hormonal and metabolic changes and observed marked reductions in indole\u20103\u2010acetic acid (59%) and abscisic acid (55%) at 8 WPG relative to 4 WPG. Protein and soluble carbohydrate reserve also declined progressively over this period. Microscopic observations revealed structural maturation of peltate glandular trichomes (PGTs) in 8\u2010week\u2010old plants, a change that may be associated with increased secretory capacity. Chromatographic analysis revealed a greater diversity of compounds at 8 WPG; carvacrol was the dominant constituent at both stages (71.65% at 4 WPG and 72.82% at 8 WPG), followed by thymol as the second most abundant compound. Overall, the findings indicate that developmental progression is accompanied by coordinated changes in hormone levels, trichome morphology, and bioactive compound profiles under controlled conditions.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71601","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:41:40Z","timestamp":1787312500000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Developmental Dynamics of Bioactive Compound Accumulation During Vegetative Growth in\n                    <i>Thymus daenensis<\/i>\n                    \u010celak"],"prefix":"10.1002","volume":"23","author":[{"given":"Ehsan","family":"Bakhshy","sequence":"first","affiliation":[{"name":"Department of Plant Biology Faculty of Biological Sciences Tarbiat Modares University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2497-5131","authenticated-orcid":false,"given":"Fatemeh","family":"Zarinkamar","sequence":"additional","affiliation":[{"name":"Department of Plant Biology Faculty of Biological Sciences Tarbiat Modares University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Nazari","sequence":"additional","affiliation":[{"name":"Department of Plant Biology Faculty of Biological Sciences Tarbiat Modares University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/hr\/uhac223"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0717\u201097072023000105807"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes14050955"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2024.1402310"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.961486"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.4563"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants13101375"},{"issue":"2","key":"e_1_2_11_9_1","first-page":"425","article-title":"Evaluating the Influence of Aloe barbadensis Extracts on Edema Induced Changes in C\u2010reactive Protein and Interleukin\u20106 in Albino Rats Through in Vivo and in Silico Approaches","volume":"70","author":"Rauf B.","year":"2023","journal-title":"Acta Biochimica Polonica"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202302115"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.onano.2023.100170"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14010068"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envexpbot.2020.104197"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","DOI":"10.1177\/1934578X20903555","article-title":"Advances in Pharmacological Activities of Terpenoids","volume":"15","author":"Yang W.","year":"2020","journal-title":"Natural Products Communications"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.4067\/s0717\u201097072023000305895"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010\u2010024\u201004875\u2010w"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u2010185X.1944.tb00302.x"},{"key":"e_1_2_11_18_1","first-page":"253","article-title":"Determination of Total Carbohydrates by Anthrone Method","volume":"34","author":"Thayermanavan V.","year":"1984","journal-title":"Plant Foods for Human Nutrition"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac60045a016"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003\u20102697(69)80009\u20106"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003\u20102697(76)90527\u20103"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.2478\/ebtj\u20102018\u20100010"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aoas.2021.04.001"},{"key":"e_1_2_11_24_1","first-page":"792","article-title":"Measurement of Total Phenolic Content and Antioxidant Activity of Aerial Parts of Medicinal Plant Coronopus Didymus. 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