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This study employed an integrated approach combining network pharmacology, bioinformatics, and in vitro experiments to analyze 45 clinical prescriptions. From the 188 herbs identified, licorice and atractylodes rhizome were the most frequently used. Analysis revealed seven key active compounds, including quercetin and stigmasterol, acting on 149 shared targets, with significant enrichment in pathways such as PI3K\/AKT. Molecular docking confirmed strong binding between core compounds and targets like PRKACA. Bioinformatics analysis of TCGA data further reveals that MMP9 may promote tumor invasion and metastasis by degrading the extracellular matrix. In vitro, quercetin and stigmasterol inhibited A549 cell proliferation and induced apoptosis, with quercetin suppressing PI3K\/AKT activation. 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