{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:09:16Z","timestamp":1788858556384,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A new library of substituted amide derivatives of coumarin\u20101,2,4\u2010thiadiazoles (12a\u2013j) was synthesized, and their chemical structures were confirmed by spectroscopic techniques. The synthesized compounds were evaluated for their in vitro anticancer activity against a panel of human cancer cell lines, including PC3 (prostate), A549 (lung), MCF\u20107 (breast), and SiHa (cervix), using the MTT assay, with etoposide as the positive control. The compounds exhibited good to moderate anticancer activity, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values ranging from 0.11 \u00b1 0.029 to 9.12 \u00b1 4.67\u00a0\u00b5M, whereas etoposide showed IC\n                    <jats:sub>50<\/jats:sub>\n                    values ranging from 2.11 \u00b1 0.024 to 3.11 \u00b1 0.11\u00a0\u00b5M. Among the synthesized derivatives, 12a, 12b, 12c, and 12d displayed remarkable anticancer potency.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71608","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:49:37Z","timestamp":1787312977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, Synthesis, and Biological Evaluation of Amide Derivatives of Coumarin\u20101,2,4\u2010Thiadiazoles as Anticancer Agents"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5016-8934","authenticated-orcid":false,"given":"Arun Kumar","family":"Lingala","sequence":"first","affiliation":[{"name":"Medicinal Chemistry Division Aragen Life Sciences Private Limited (Previously Known As GVK Biosciences Private Limited)  Hyderabad Telangana India"},{"name":"Department of Chemistry Chaitanya (Deemed to Be University)  Warangal Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran Kumar","family":"Murahari","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Division Aragen Life Sciences Private Limited (Previously Known As GVK Biosciences Private Limited)  Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4465-042X","authenticated-orcid":false,"given":"Laxminarayana","family":"Eppakayala","sequence":"additional","affiliation":[{"name":"Department of Chemistry School of Engineering Anurag University  Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder","family":"Manchal","sequence":"additional","affiliation":[{"name":"Department of Chemistry Chaitanya (Deemed to Be University)  Warangal Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(24)38050-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703932"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.04.021"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/17568919.2024.2444867"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42452\u2010025\u201007678\u20108"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo01060a039"},{"key":"e_1_2_9_8_1","first-page":"684","article-title":"Coumarin compounds in Ammi majus L. callus cultures","volume":"55","author":"Ekiert H.","year":"2000","journal-title":"Die Pharmazie"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044\u2010013\u20100724\u2010z"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cber.19360690533"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cber.19370700306"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1246\/bcsj.11.389"},{"key":"e_1_2_9_13_1","first-page":"475","article-title":"Determination of the Coumarinic Constituents of Ficus carica Leaves by HPLC","volume":"37","author":"Innocenti G.","year":"1982","journal-title":"Farmaco Scientifica"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2024.101794"},{"key":"e_1_2_9_15_1","first-page":"1289","article-title":"Cytotoxic and Antitumor Activity of some coumarin Derivatives","volume":"11","author":"Garro H. 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