{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:09:13Z","timestamp":1788858553442,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Human schistosomiasis is a neglected tropical disease affecting millions worldwide, highlighting the need for affordable alternative therapies. This study evaluated the in vitro antischistosomal activity of the\n                    <jats:italic>Capsicum annuum<\/jats:italic>\n                    methanolic extract against adult\n                    <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    . Tegumental alterations were examined by scanning electron microscopy (SEM), while potential molecular targets were investigated using STITCH network analysis, molecular docking, and in silico pharmacokinetic prediction. Concentrations of\n                    <jats:italic>C. annuum<\/jats:italic>\n                    extract (20\u2013320\u00a0\u00b5g\/mL) and praziquantel (0.2\u00a0\u00b5g\/mL) were evaluated for time\u2010dependent worm mortality at 1, 3, 12, 24, 48, and 72\u00a0h post\u2010treatment. Praziquantel induced 100% mortality within 24\u00a0h, whereas the dose (320\u00a0\u00b5g\/mL) caused 50% mortality at 24\u00a0h and complete mortality at 48\u00a0h. Docking analysis suggested apoptosis\u2010related proteases and a Ser\/Thr kinase as putative molecular targets that warrant further experimental validation. These findings demonstrate that\n                    <jats:italic>C. annuum<\/jats:italic>\n                    methanolic extract possesses promising antischistosomal activity against\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71610","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:54:16Z","timestamp":1787313256000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phytochemical Characterization, Molecular Docking Analysis, and In Vitro Antischistosomal Activity of\n                    <i>Capsicum annuum<\/i>\n                    Methanolic Extract"],"prefix":"10.1002","volume":"23","author":[{"given":"Amina A.","family":"Ghedan","sequence":"first","affiliation":[{"name":"Department of Zoology and Entomology, Faculty of Science Capital University Cairo 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