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However, the long\u2010term use of these drugs is associated with adverse effects and the development of dependence, driving the search for safer therapeutic alternatives. (+)\u2010Dihydrocarvone is a monoterpene ketone with documented biological activities, including antifungal, antiparasitic, and anti\u2010inflammatory effects. This study utilized adult zebrafish (*Danio rerio*), an animal model widely used in pharmacological and behavioral research due to its neurobiological similarity to mammals. Toxicity tests, assessments of anxiolytic activity and memory effects, and *in silico* studies were conducted. The results demonstrated anxiolytic\u2010like effects and memory preservation associated with (+)\u2010dihydrocarvone, with pharmacological data suggesting the possible involvement of GABAergic and serotonergic pathways. Furthermore, molecular interaction analyses revealed affinity for the GABA\u223cA receptor, indicating a potential pharmacological effect.<\/jats:p>","DOI":"10.1002\/cbdv.71612","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:31:14Z","timestamp":1787311874000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evidence for the Induction of Anxiolytic\u2010Like Behavior and Memory Preservation by (+)\u2010Dihydrocarvone Through Studies in Adult Zebrafish and In S\u00edlico"],"prefix":"10.1002","volume":"23","author":[{"given":"Isadora Freitas","family":"de Sousa","sequence":"first","affiliation":[{"name":"Graduate Program in Natural Sciences Campus Itaperi State University of Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8357-6707","authenticated-orcid":false,"given":"Francisco 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