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This study investigated the chemical composition and biological activities of geopropolis from four\n                    <jats:italic>Melipona<\/jats:italic>\n                    species collected in the Brazilian Atlantic Forest during the dry and rainy seasons. Hydroalcoholic extracts were quantified for total phenolics, flavonoids, tannins, and characterized by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI(\u2010)\u2010FT\u2010ICR MS), allowing the tentative assignment of 56 compounds, mainly phenolic acids, flavonoids, and terpenoids. Antioxidant activity was evaluated using DPPH and ABTS assays, anti\u2010inflammatory activity by measuring nitric oxide, superoxide anion, and TNF\u2010\u03b1 production in LPS\u2010stimulated macrophages, and antifungal activity against selected pathogenic strains. The extracts exhibited significant interspecific variation in phenolic composition and antioxidant activity (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05), with\n                    <jats:italic>Melipona bicolor<\/jats:italic>\n                    showing the highest antioxidant capacity, reflected by the lowest DPPH and ABTS IC\n                    <jats:sub>50<\/jats:sub>\n                    values. Geopropolis extracts also significantly reduced nitric oxide, superoxide anion, and TNF\u2010\u03b1 production (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05) and displayed selective antifungal activity. Seasonal variation influenced metabolite composition and biological activities, providing new insights into the chemical diversity and biological potential of geopropolis from native Atlantic Forest stingless bees.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71615","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:02:43Z","timestamp":1787680963000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemical Composition and Biological Activities of Geopropolis From Four\n                    <i>Melipona<\/i>\n                    Species From the Brazilian Atlantic Forest"],"prefix":"10.1002","volume":"23","author":[{"given":"Ariane Pinheiro Cruz","family":"Bergamini","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas Universidade Vila Velha  Vila Velha Espirito Santo 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Sousa","family":"Cutrim","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas Universidade Vila Velha  Vila Velha Espirito Santo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Paulo Mesquita","family":"Arag\u00e3o","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas Universidade Vila Velha  Vila Velha Espirito Santo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor da Rocha","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Petroleomics and Forensic Laboratory Universidade Federal do Esp\u00edrito Santo (UFES)  Vit\u00f3ria Espirito Santo 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