{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:13Z","timestamp":1790546173666,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study reports the synthesis, characterization, and biological evaluation of a novel Nd(III) complex with a newly designed Schiff base H\n                    <jats:sub>2<\/jats:sub>\n                    L derived from 2\u2010hydroxy\u20101\u2010naphthaldehyde and\n                    <jats:sc>l<\/jats:sc>\n                    \u2010histidine. The coordination, structure, and formula were determined using elemental analysis, molar conductivity, FT\u2010IR and\n                    <jats:sup>1<\/jats:sup>\n                    HNMR spectroscopies, TGA, and XRD. The ligand acts as a tetradentate donor and a distorted octahedral geometry was proposed for the Nd(III) complex, coordinating via azomethine nitrogen and phenolic oxygen atoms. The cytotoxic activity of the ligand and its Nd(III) complex was evaluated against MCF\u20107 (breast), PC\u20103 (prostate), and A\u2010549 (lung) human cancer cell lines using the MTT assay after 48 h. The inhibition rates of the complex were 97.19%, 95.73%, and 92.11% against A\u2010549, PC\u20103, and MCF\u20107, respectively. Quantum chemical calculations revealed that the ligand exhibited two isoenergetic isomers stabilized by intramolecular hydrogen bonds. For [Nd\n                    <jats:sup>III<\/jats:sup>\n                    (HL)(NO\n                    <jats:sub>3<\/jats:sub>\n                    )\n                    <jats:sub>2<\/jats:sub>\n                    ], two isomers (A and B) were proposed, differing in the deprotonation site; Isomer B was more stable than A (\u0394\n                    <jats:italic>G<\/jats:italic>\n                    = \u221237.6 kJ\u2022mol\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) at 298.15 K and 1.00 atm. The experimental results reveal that the cytotoxic activity of the ligand is improved upon coordination with Nd(III) and the complex could be a promising candidate for development a new lanthanide\u2010based anticancer agent.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71616","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:18:35Z","timestamp":1788200315000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis, Structural Elucidation, and Anticancer Efficacy Evaluation of a Novel Nd(III)\u2010Schiff Base Complex: Experimental and Computational Insights"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1896-9285","authenticated-orcid":false,"given":"Basma A. A.","family":"Balboul","sequence":"first","affiliation":[{"name":"Chemistry Department College of Science Jouf University Sakaka Aljouf Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3501-2787","authenticated-orcid":false,"given":"Rania H.","family":"Taha","sequence":"additional","affiliation":[{"name":"Chemistry Department College of Science Jouf University Sakaka Aljouf Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5989-8308","authenticated-orcid":false,"given":"Ibtisam","family":"Alali","sequence":"additional","affiliation":[{"name":"Chemistry Department College of Science Jouf University Sakaka Aljouf Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8170-426X","authenticated-orcid":false,"given":"Nada","family":"Alhathlaul","sequence":"additional","affiliation":[{"name":"Chemistry Department College of Science Jouf University Sakaka Aljouf Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9957-1737","authenticated-orcid":false,"given":"Alaa M.","family":"Alsirhani","sequence":"additional","affiliation":[{"name":"Chemistry Department College of Science Jouf University Sakaka Aljouf Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3283-8759","authenticated-orcid":false,"given":"Aml M.","family":"Saleh","sequence":"additional","affiliation":[{"name":"Chemistry Department Faculty of Science (Girls) Al\u2010Azhar University  Nasr City Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3039-7646","authenticated-orcid":false,"given":"Tarek A.","family":"Yousef","sequence":"additional","affiliation":[{"name":"College of Science Chemistry Department Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4614-1568","authenticated-orcid":false,"given":"Enrico","family":"Benassi","sequence":"additional","affiliation":[{"name":"TIES Srl Piazza Renato Simoni 1 Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dyepig.2025.112710"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00195A"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2024.216327"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2018.06.104"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.140211"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2024.125034"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.70067"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.201702730"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4314\/bcse.v38i2.7"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00958970601053776"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22020153"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.btre.2025.e00916"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/futurepharmacol5010004"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2026.103555"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matpr.2021.10.360"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2023.111826"},{"key":"e_1_2_11_19_1","volume-title":"Infrared and Raman Spectra of Inorganic and Coordination Compounds, Part B: Applications in Coordination, Organometallic, and Bioinorganic Chemistry","author":"Nakamoto K.","year":"2008"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2023.136386"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.138830"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2023.111796"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2023.123274"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.6715"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2023.110465"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2023.101231"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2023.110826"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2020.128911"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.138115"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2023.122698"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2023.111453"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2023.136156"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.140223"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5ma00567a"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2023.116542"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.140335"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.134676"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2023.112393"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9261683"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC05478C"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/app13095561"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2024.216327"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.11.11.9285481"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2614(89)87234-3"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.464913"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21759"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/ct049977a"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cplett.2004.06.011"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/1539445X.2020.1714656"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.540110311"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp512342y"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0104(81)85156-7"},{"key":"e_1_2_11_53_1","unstructured":"M.Frisch G.Trucks andH. B.Schlegel Gaussian 09 Revision A.1 (Gaussian Inc 2009)."},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2074-7_26"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71616","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.71616","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71616","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:56:48Z","timestamp":1790542608000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.71616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":53,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/cbdv.71616"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.71616","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]},"assertion":[{"value":"2026-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71616"}}