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The fungus\n                    <jats:italic>Penicillium crustosum<\/jats:italic>\n                    is an important source of bioactive natural products that display significant antibacterial properties. This study describes the isolation and characterization of two new structures including one \u03b3\u2010unsaturated lactone named crustosulin A and one aliphatic acid named crustosenoic acid A along with ten known compounds from a marine\u2010derived fungus\n                    <jats:italic>Penicillium crustosum<\/jats:italic>\n                    HDN17\u201068, which is isolated from the Western Pacific deep\u2010sea mud sample. Compounds were isolated and purified through column chromatography and HPLC, and structures were elucidated using spectroscopic tools including NMR, MS, and ECD. Compound\n                    <jats:bold>1<\/jats:bold>\n                    represents the first example of a dimeric\n                    <jats:italic>\u03b3<\/jats:italic>\n                    \u2010unsaturated butyrolactone incorporating a\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010to\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    connectivity and it exhibited weak activity against\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    and methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA), with MIC values of 32 and 64\u00a0\u00b5g\/mL, respectively. These findings expand the chemical diversity of secondary metabolites from deep\u2010sea\u2010derived\n                    <jats:italic>Penicillium<\/jats:italic>\n                    fungi.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71620","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:38:47Z","timestamp":1789465127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["New\n                    <i>\u03b3<\/i>\n                    \u2010Unsaturated Lactone and Aliphatic Acid From the Deep\u2010Sea\u2010Derived Fungus\n                    <i>Penicillium crustosum<\/i>\n                    HDN17\u201068"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6132-8622","authenticated-orcid":false,"given":"Naritsara","family":"Yusawat","sequence":"first","affiliation":[{"name":"Key Laboratory of Marine Drugs Chinese Ministry of Education School of Medicine and Pharmacy Ocean University of China Qingdao China"},{"name":"Department of Fishery Products Faculty of Fisheries Kasetsart University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3469-1765","authenticated-orcid":false,"given":"Wenxue","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs Chinese Ministry of Education School of Medicine and Pharmacy Ocean University of China Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Deng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs Chinese Ministry of Education School of Medicine and Pharmacy Ocean University of China Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2176-195X","authenticated-orcid":false,"given":"Hengyi","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs Chinese Ministry of Education School of Medicine and Pharmacy Ocean University of China Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanteng","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs Chinese Ministry of Education School of Medicine and Pharmacy Ocean University of China Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7191-2002","authenticated-orcid":false,"given":"Dehai","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs Chinese Ministry of Education School of Medicine and Pharmacy Ocean University of China Qingdao China"},{"name":"Laboratory For Marine Drugs and Bioproducts Qingdao Marine Science and Technology Center  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanwimol","family":"Klaypradit","sequence":"additional","affiliation":[{"name":"Department of Fishery Products Faculty of Fisheries Kasetsart University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juta","family":"Mookdasanit","sequence":"additional","affiliation":[{"name":"Department of Fishery Products Faculty of Fisheries Kasetsart University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4976-8083","authenticated-orcid":false,"given":"Guojian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs Chinese Ministry of Education School of Medicine and Pharmacy Ocean University of China Qingdao China"},{"name":"Laboratory For Marine Drugs and Bioproducts Qingdao Marine Science and 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