{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:10Z","timestamp":1790546170330,"version":"4.1.0"},"reference-count":75,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This work investigates the carboxymethylcellulose (CMC)\u2010dates (Dt) hydrogel films (HFs) for the controlled delivery of hydrophobic drugs, using citric acid (CA) as a nontoxic cross\u2010linking agent. The model drug Econazole (ECN) was loaded into HFs, and drug release was studied at pH 7.4. The HFs were evaluated for \u03b2\u2010cyclodextrin (\u03b2\u2010CD) content, carboxyl content, swelling ratio, drug loading, drug release, and in vivo anti\u2010inflammatory activity. These films were characterized using ATR\u2010FTIR, thermal gravimetric analysis (TGA), scanning electron microscopy coupled with energy\u2010dispersive x\u2010ray spectroscopy (SEM\/EDX), and atomic force microscopy (AFM) for morphological measurements. Results revealed that the HFs with high carboxyl content exhibit maximum swelling and high drug loading. The incorporation of \u03b2\u2010CD helped to retard the release of ECN from the HFs. Our findings indicate that HFs F3 and F4 with high Dt concentrations reduce the edematous response by 92% \u00b1 5.07% and 89% \u00b1 3.69%, respectively. Altogether, our findings show that CMC\u2010Dt HFs are suitable for the delivery of non\u2010soluble weak bases and have potential for wound\u2010healing applications. The in vivo investigation demonstrated that the HFs exhibit significant anti\u2010inflammatory characteristics.<\/jats:p>","DOI":"10.1002\/cbdv.71622","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:35:19Z","timestamp":1788201319000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preparation, Characterization, and Evaluation of \u03b2\u2010Cyclodextrin Inclusion Hydrogel Films Based on Dates Carboxymethyl Cellulose for Hydrophobic Drug Delivery"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0613-1340","authenticated-orcid":false,"given":"Loubna","family":"Oumamar","sequence":"first","affiliation":[{"name":"Laboratory of Applied Biochemistry Setif\u20101 University of Ferhat Abbas 19000 Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8205-3605","authenticated-orcid":false,"given":"El Khamsa","family":"Soltani","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Biochemistry Setif\u20101 University of Ferhat Abbas 19000 Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1789-3592","authenticated-orcid":false,"given":"Kailas Krishnat","family":"Mali","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics Adarsh College of Pharmacy  Vita Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahlem","family":"Karbab","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Biochemistry Setif\u20101 University of Ferhat Abbas 19000 Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noureddine","family":"Charef","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Biochemistry Setif\u20101 University of Ferhat Abbas 19000 Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Sowan","sequence":"additional","affiliation":[{"name":"Department of Chemistry The University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9782-0835","authenticated-orcid":false,"given":"Mohammad S.","family":"Mubarak","sequence":"additional","affiliation":[{"name":"Department of Chemistry The University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.121339"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359\u20100294(97)80103\u20103"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2018.05.023"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14245432"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.02.044"},{"key":"e_1_2_10_7_1","unstructured":"J. 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