{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:11Z","timestamp":1790546171856,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The increasing resistance to existing antimalarial agents has prompted researchers to develop new therapeutic candidates. To address this, the hybridization of 1,4\u2010naphthoquinone and 1,2,3\u2010triazole yielded a new series of compounds evaluated as prospective in vitro antimalarial agents against the chloroquine\u2010sensitive 3D7 and chloroquine\u2010resistant K1 strains of\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    . The target compounds were synthesized efficiently via a multistep route, involving the reaction of 1,4\u2010naphthoquinone and\n                    <jats:italic>p<\/jats:italic>\n                    \u2010aminobenzoic acid, followed by reactions with propargylamine and different prepared chlorides. The synthetic route was concluded using a copper(I)\u2010catalyzed azide\u2010alkyne cycloaddition (CuAAC) \u201cclick\u201d reaction. Based on structure\u2010activity relationships (SAR), the compound bearing a 4\u2010chloroaryl moiety (\n                    <jats:bold>9g<\/jats:bold>\n                    ) was the most active against\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    3D7, exhibiting 60.00% growth inhibition at 25\u00a0\u00b5M. Furthermore, compound\n                    <jats:bold>9k<\/jats:bold>\n                    bearing a 2\u2010methylaryl moiety exhibited the most potent activity against\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    K1, showing 64.52% growth inhibition at 50\u00a0\u00b5M. In silico simulations of compound\n                    <jats:bold>9g<\/jats:bold>\n                    on thirteen protein targets in\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    indicated strong interactions with the 1J3 and 1LDG targets. Also, the stability of the ligand\u2010protein complexes was verified for 3FGO.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71631","type":"journal-article","created":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:16:33Z","timestamp":1789931793000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, Synthesis, and Evaluation of New 1,4\u2010Naphthoquinone\u20101,2,3\u2010triazoles as Antimalarial Agents"],"prefix":"10.1002","volume":"23","author":[{"given":"Lina","family":"Rezainia","sequence":"first","affiliation":[{"name":"Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hosein","family":"Sayahi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Payame Noor University  Tehran 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Clinical Sciences Institute Tehran University of Medical Sciences  Tehran Iran"},{"name":"School of Chemistry, College of Science University of Tehran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navid","family":"Dastyafteh","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8403-8190","authenticated-orcid":false,"given":"Mehdi","family":"Nateghpour","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Mycology, School of Public Health Tehran University of Medical Sciences (TUMS)  Tehran Iran"},{"name":"Center For Research of Endemic Parasites of Iran Tehran University of Medical Sciences (TUMS)  Tehran 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