{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:12Z","timestamp":1790546172836,"version":"4.1.0"},"reference-count":90,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study characterized the phytochemical composition of a methanolic bark extract of\n                    <jats:italic>Cinnamomum verum<\/jats:italic>\n                    and evaluated its antibacterial, bactericidal, biofilm\u2010biomass\u2010reducing, and preliminary antibiotic\u2010potentiating effects against reference and multidrug\u2010resistant bacterial strains. The extract was characterized by HPLC\u2010MS; MIC and MBC values were determined by broth microdilution; biofilm biomass was assessed using the crystal\u2010violet assay; and antibiotic\u2010extract interactions were screened by disk diffusion. Molecular docking was used as a hypothesis\u2010generating approach to investigate interactions between identified phytochemicals and GyrB, LasA, and PBP1a. Seventeen compounds were identified, with trans\u2010cinnamaldehyde as the predominant quantified constituent, followed by quinic acid, rutin, and protocatechuic acid. The extract inhibited all tested bacteria, with MIC and MBC values of 0.625\u20135 and 2.5\u201320\u00a0mg\/mL, respectively, and MBC\/MIC ratios consistent with bactericidal activity. Imipenem\u2010resistant\n                    <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    isolates were the most susceptible. The extract also reduced biofilm biomass in a concentration\u2010dependent and strain\u2010dependent manner. Disk\u2010diffusion screening identified antibiotic\u2010 and isolate\u2010dependent increases in inhibition zones, particularly for cefoxitin and fosfomycin against MRSA and for selected combinations against\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    ; however, some combinations were unchanged or produced smaller zones, and pharmacological synergy was not established. Docking prioritized quercetin, 1,3\u2010di\u2010O\u2010caffeoylquinic acid, and quercetin\u20103\u2010O\u2010rhamnoside as candidates for subsequent target\u2010based validation.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71634","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:33:46Z","timestamp":1788201226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antibacterial and Antibiofilm Activity of a Chemically Characterized\n                    <i>Cinnamomum verum<\/i>\n                    Bark Methanolic Extract Against Multidrug\u2010Resistant Bacteria: Preliminary Antibiotic\u2013Interaction Screening and Exploratory Molecular Docking"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2905-8129","authenticated-orcid":false,"given":"Hayet","family":"Edziri","sequence":"first","affiliation":[{"name":"Laboratory of Transmissible Diseases and Biologically Active Substances, (LR99ES27), Faculty of Pharmacy University of Monastir  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6352-814X","authenticated-orcid":false,"given":"Sarra","family":"Elmsehli","sequence":"additional","affiliation":[{"name":"Laboratory of Transmissible Diseases and Biologically Active Substances, (LR99ES27), Faculty of Pharmacy University of Monastir  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9211-3517","authenticated-orcid":false,"given":"Assia","family":"kenich","sequence":"additional","affiliation":[{"name":"Laboratory of Organic Chemistry Natural Substances and Analysis (C.O.S.N.A.) Abu Bekr Belkaid University  Tlemcen Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2650-2634","authenticated-orcid":false,"given":"Mabrouk","family":"Horchani","sequence":"additional","affiliation":[{"name":"Laboratory Of\u00a0Heterocyclic Chemistry, Natural Products and\u00a0Reactivity, Medicinal Chemistry and\u00a0Natural Products (LR11ES39), Department of\u00a0Chemistry, Faculty of\u00a0Sciences Of\u00a0Monastir University Of\u00a0Monastir  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5311-4218","authenticated-orcid":false,"given":"Hanen","family":"Najjaa","sequence":"additional","affiliation":[{"name":"Institute of Arid Land (IRA) Range Ecology Laboratory  M\u00e9denine Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naima","family":"Najah","sequence":"additional","affiliation":[{"name":"Laboratory of Transmissible Diseases and Biologically Active Substances, (LR99ES27), Faculty of Pharmacy University of Monastir  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Aljohi","sequence":"additional","affiliation":[{"name":"Applied Genetics Technology Institute King Abdulaziz City For Science and Technology  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Nasser","family":"Alkhrayef","sequence":"additional","affiliation":[{"name":"Disability Research Institute King Abdulaziz City For Science and Technology  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1791-8208","authenticated-orcid":false,"given":"Roberta","family":"Ascrizzi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2418-9349","authenticated-orcid":false,"given":"Guido","family":"Flamini","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8479-7875","authenticated-orcid":false,"given":"Ibrahim O.","family":"Alanazi","sequence":"additional","affiliation":[{"name":"The Healthy Aging Research Institute King Abdulaziz City For Science and Technology  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4076-2443","authenticated-orcid":false,"given":"Mozaniel Santana","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology of Inflammation and Behavior, Institute of Health Sciences, Postgraduate Program in Pharmaceutical Sciences (PPGCF) Federal University of Par\u00e1.  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.glmedi.2024.100081"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens15030288"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70447"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1137947"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s44351\u2010025\u201000035\u20105"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a012427"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252312808"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens11030292"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/microbiolres16080183"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1215437"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-99476-1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101\u2010026\u201010282\u20102"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants12173077"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trmm.2026.100002"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics13080746"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14060555"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.engmic.2026.100273"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1590\/0001\u20103765201920180117"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2023.103576"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppp3.10192"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.600139"},{"key":"e_1_2_10_23_1","first-page":"1","volume-title":"Bioactive Compounds in Underutilized Vegetables and Legumes","author":"Pasupuleti V. R.","year":"2021"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-33505-1"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12020254"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052752"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods12030452"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2017.1369102"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26136482"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7095359"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2018.04.036"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14080842"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b00694"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3934\/microbiol.2022019"},{"key":"e_1_2_10_35_1","volume-title":"Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated from Animals; Informational Supplement","author":"Shryock T. R. A.","year":"2004"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e01604"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201095343\u2010w"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05485\u201011"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.12.021"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja208835z"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21334"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25112641"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods10071666"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2018.03.060"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules31132265"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202400723"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787\u2010025\u201001671\u20108"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1540638"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2014.05.078"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2009.03.023"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010026\u201044279\u2010w"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28176403"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2020.110101"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijfs.12898"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12020128"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.focha.2026.101226"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14060725"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkae380"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28031114"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.70478"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10020188"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics13111095"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10060702"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu18020267"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1155\/ijm\/9961121"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1659743"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11061614"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14080802"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13205\u2010021\u201002707\u2010w"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2017.1313372"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2020.1193"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11010087"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb48020214"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2005.02.004"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2020.104482"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13122176"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms14030618"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8030455"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16111531"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.3390\/app16094414"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.61186\/mlj.17.6.1"},{"key":"e_1_2_10_82_1","first-page":"001","article-title":"Ethanolic and Aqueous Extracts of Cinnamon (Cinnamomum Verum) Bark Against Selected Microbes","volume":"25","author":"Al\u2010Garadi M.","year":"2023","journal-title":"Brazilian Journal Poult Science"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.2139\/ssrn.4450001"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1088\/1755\u20101315\/130\/1\/012049"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100041\u20101742125"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fpsl.2023.101026"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matpr.2020.10.377"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.131523"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10051026"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.130864"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11030\u2010021\u201010190\u2010x"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71634","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.71634","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71634","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:56:54Z","timestamp":1790542614000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.71634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":90,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/cbdv.71634"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.71634","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]},"assertion":[{"value":"2026-05-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71634"}}