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Their structures were verified by\n                    <jats:sup>1<\/jats:sup>\n                    H NMR,\n                    <jats:sup>13<\/jats:sup>\n                    C NMR, and HRMS. The structure of compound\n                    <jats:bold>X9<\/jats:bold>\n                    was further confirmed via X\u2010ray crystallography. Their antifungal activities against five phytopathogenic fungi were evaluated to develop isoquinoline\u2010based antifungal agents. Among them, compound\n                    <jats:bold>X6<\/jats:bold>\n                    demonstrated significant antifungal activity against\u00a0\n                    <jats:italic>Botrytis cinerea<\/jats:italic>\n                    with an EC\n                    <jats:sub>50<\/jats:sub>\n                    value of 7.55\u00a0\u00b5g\/mL.\n                    <jats:italic>In vivo<\/jats:italic>\n                    assays revealed that compound\n                    <jats:bold>X6<\/jats:bold>\n                    exhibited strong protective and curative efficacy against\n                    <jats:italic>B. cinerea<\/jats:italic>\n                    with rates of 77.86% and 45.45% at a concentration of 100\u00a0\u00b5g\/mL. Molecular docking studies confirmed that isoquinoline amide compounds possess strong binding affinity to succinate dehydrogenase (SDH). Molecular dynamics (MD) simulations revealed that compound\n                    <jats:bold>X6<\/jats:bold>\n                    has better pocket spatial compatibility and more stable binding interactions with SDH than boscalid. Furthermore, SDH activity assays showed compound\n                    <jats:bold>X6<\/jats:bold>\n                    inhibited SDH activity by 66.7% at 4 EC\n                    <jats:sub>50<\/jats:sub>\n                    concentration, which was comparable to that of the boscalid (75.85%). These findings demonstrated that isoquinoline derivatives incorporating the phenoxypyridine fragment possess potent fungicidal properties for crop safety, with compound\n                    <jats:bold>X6<\/jats:bold>\n                    emerging as a promising candidate for a novel SDH inhibitor.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71635","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:23:29Z","timestamp":1789035809000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis and Antifungal Evaluation of Isoquinoline\u20103\u2010amide Derivatives Containing a Phenoxypyridine Moiety for Plant Protection"],"prefix":"10.1002","volume":"23","author":[{"given":"Jiayao","family":"Zhang","sequence":"first","affiliation":[{"name":"Jiangxi Provincial Key Laboratory of Organic Functional Molecules Institute of Organic Chemistry Jiangxi Science and Technology Normal University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaipeng","family":"Sun","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory of Organic Functional Molecules Institute of Organic Chemistry Jiangxi Science and Technology Normal University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Guo","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory of Organic Functional Molecules Institute of Organic Chemistry Jiangxi Science and Technology Normal University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Environment and Plant Protection Institute Chinese Academy of Tropical Agricultural Science  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Environment and Plant Protection Institute Chinese Academy of Tropical Agricultural Science  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0338-6458","authenticated-orcid":false,"given":"Gang","family":"Feng","sequence":"additional","affiliation":[{"name":"Environment and Plant Protection Institute Chinese Academy of Tropical Agricultural Science  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1569-7333","authenticated-orcid":false,"given":"Haixin","family":"Ding","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory of Organic Functional Molecules Institute of Organic Chemistry Jiangxi Science and Technology Normal University  Nanchang 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