{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:12Z","timestamp":1790546172943,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A series of 1,3\u2010oxazolidine nucleoside analogues (1\u20106) was designed and synthesized for their anti\u2010HIV activity. The purpose of this study was to determine whether the antiviral activity of the pyrimidine ring is affected by oxazolidine ring substitution. The synthesized compounds were tested for their HIV\u20101 RT inhibitory activity by a colorimetric HIV reverse transcriptase (HIVRT) test. The fluoro (\n                    <jats:bold>S4<\/jats:bold>\n                    ) and bromo (\n                    <jats:bold>S5<\/jats:bold>\n                    ) derivatives of these compounds showed the highest HIV\u20101 reverse transcriptase IC\n                    <jats:sub>50<\/jats:sub>\n                    values, 19.27 and 22.80\u00a0\u00b5M, respectively. Modest activity was observed for the remaining compounds. The molecular docking experiments with the crystal structure of HIV\u20101 reverse transcriptase (PDB ID: 1RT1) revealed that\n                    <jats:bold>S4<\/jats:bold>\n                    and\n                    <jats:bold>S5<\/jats:bold>\n                    have good binding affinities of \u22127.6 and \u22127.3\u00a0kcal\/mol, respectively, with multiple hydrogen bonds and \u03c0\u2010interactions with key residues in the active site. The properties of all the synthesized compounds were found to be in accordance with Lipinski Rule of Five and showed a favorable ADME profile, indicating good drug\u2010likeness, acceptable solubility, and potential oral bioavailability. Halogen substitution enhances electronic dispersion and hydrophobic interactions, but the oxazolidine scaffold is superior to thiazolidine scaffolds. Halogenated oxazolidine compounds are generally promising HIV\u20101 reverse transcriptase inhibitors.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71638","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:02:56Z","timestamp":1790539376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, Synthesis, In Silico Studies, and HIV\u20101 RT Inhibitory Activity of 1,3\u2010Oxazolidine Pyrimidine Nucleoside Analogues"],"prefix":"10.1002","volume":"23","author":[{"given":"Shimoga Nagaraj","family":"Sriharsha","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry National College of Pharmacy Shimoga India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4445-954X","authenticated-orcid":false,"given":"Zaid Mahmood","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry College of Pharmacy Al\u2010Zahraa University for Women  Karbala Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4915-417X","authenticated-orcid":false,"given":"Ammar A. Razzak","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Al Ma'moon University 14\u2010Ramadan Street Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibghatullah Muhammad Ali","family":"Sangi","sequence":"additional","affiliation":[{"name":"Basic Medical Sciences Department Dar Al Uloom University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0176-3504","authenticated-orcid":false,"given":"Sadik","family":"Shaik","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Anuradha College of Pharmacy  Bengaluru India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2058-255X","authenticated-orcid":false,"given":"Sreeharsha","family":"Nagaraja","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Clinical Pharmacy King Faisal University  Al\u2010Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheeba","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Nursing College of Applied Medical Sciences King Faisal University  Al\u2010Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7006-3694","authenticated-orcid":false,"given":"Vidhya","family":"Thirunavukkarasu","sequence":"additional","affiliation":[{"name":"Department of Nursing College of Applied Medical Sciences King Faisal University  Al\u2010Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavan Kumar","family":"Sreenivasalu","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry and Endodontics College of Dentistry King Faisal University  Al\u2010Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8010-4712","authenticated-orcid":false,"given":"Monirul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences College of Clinical Pharmacy King Faisal University  Al\u2010Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Shahzad","family":"Chohan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences College of Clinical Pharmacy King Faisal University  Al\u2010Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3928-2338","authenticated-orcid":false,"given":"Mahalakshmi Suresha","family":"Biradar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry National College of Pharmacy Shimoga India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202000849"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026615666150915111933"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr950066q"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01215"},{"key":"e_1_2_13_6_1","volume-title":"An (R)\u20104\u2010Phenyl\u20101, 3\u2010Oxazolidine\u20102\u2010Thione Mediated Approach to 2, 3\u2010Disubstituted Oxetanes and the Key Hydroxyethyl Isostere of the HIV Protease Inhibitor Darunavir. 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