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This study investigated the antiglycation, antioxidant, anti\u2010amyloidogenic, and predicted drug\u2010likeness properties of\u00a0\n                    <jats:italic>Pandanus odorifer<\/jats:italic>\n                    \u00a0(Forssk.) Kuntze. The methanolic crude extract showed high total flavonoid content (121.7\u00a0\u00b1\u00a02.50\u00a0mg QE\/g), moderate total phenolic content (16.61\u00a0\u00b1\u00a01.50\u00a0mg GAE\/g), and strong AGE inhibition (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 57.30\u00a0\u00b5g\/mL), with moderate radical scavenging activity. Chromatographic separation yielded syringaresinol (\n                    <jats:bold>1<\/jats:bold>\n                    ), dehydrovomifoliol (\n                    <jats:bold>2<\/jats:bold>\n                    ), and blumenol C glucoside (\n                    <jats:bold>3<\/jats:bold>\n                    ), identified through spectroscopic analysis and comparison with published data. In the Thioflavin T assay, compounds\n                    <jats:bold>1\u20133<\/jats:bold>\n                    reduced A\u03b2\u2010associated fluorescence, with compound 3 producing the largest reduction (71.20%\u00a0\u00b1\u00a04.42%) under the tested conditions. Molecular docking suggested interactions with A\u03b242 oligomers and AD\u2010related enzymes, particularly acetylcholinesterase and \u03b2\u2010secretase, while in silico prediction indicated acceptable drug\u2010likeness without Lipinski violations. Overall, the findings identify\n                    <jats:italic>P. odorifer<\/jats:italic>\n                    as a source of constituents with antiglycation activity and preliminary A\u03b2\u2010associated ThT responses that warrant confirmation using orthogonal biophysical and biological assays.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71641","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:29:09Z","timestamp":1788200949000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antiglycation and Amyloid\u2010\u03b2 Inhibitory Activities of\n                    <i>Pandanus odorifer<\/i>\n                    Extracts and Isolated Constituents: In Vitro and Molecular Docking Insights"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6036-7846","authenticated-orcid":false,"given":"Patricia Marie P.","family":"Oliva","sequence":"first","affiliation":[{"name":"The Graduate School University of Santo Tomas  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9328-4388","authenticated-orcid":false,"given":"Sarleen G.","family":"Castro","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences Chiba University  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4062-223X","authenticated-orcid":false,"given":"Joe Anthony H.","family":"Manzano","sequence":"additional","affiliation":[{"name":"College of Science University of Santo Tomas  Manila Philippines"},{"name":"Research Center for the Natural and Applied Sciences University of Santo Tomas  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3884-2583","authenticated-orcid":false,"given":"Hayato","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences Chiba University  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0422-8120","authenticated-orcid":false,"given":"Mario A.","family":"Tan","sequence":"additional","affiliation":[{"name":"The Graduate School University of Santo Tomas  Manila Philippines"},{"name":"College of Science University of Santo Tomas  Manila Philippines"},{"name":"Research Center for the Natural and Applied Sciences University of Santo Tomas  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.1c00206"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2026.109778"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/17568919.2025.2559573"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2025.108683"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010026\u201005973\u2010y"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5RA07416A"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.609073"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2020.109300"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-026-05347-0"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2026.2664597"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10091479"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010170543"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.70714"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2026.103406"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-026-03177-w"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00217-025-04921-9"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology11020212"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929866526666190301115122"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ympev.2014.11.002"},{"key":"e_1_2_9_21_1","first-page":"383","article-title":"Antioxidant, Anti\u2010Cancer and Antimicrobial Activities of Ethanol Pandanus amaryllifolius Roxb. 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