{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:11Z","timestamp":1790546171882,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The stem bark essential oil of\n                    <jats:italic>Magnolia officinalis<\/jats:italic>\n                    (\n                    <jats:italic>M. officinalis<\/jats:italic>\n                    ) Rehder &amp; E.H. Wilson was investigated for its chemical composition, biological activities, and in silico interactions. From the GC\u2013FID\/MS analysis, the sample was dominated by sesquiterpene hydrocarbons (85.38% \u00b1 0.04%). The major constituents were (\n                    <jats:italic>E<\/jats:italic>\n                    )\u2010caryophyllene (21.69% \u00b1 0.020%), \u03b1\u2010selinene (10.13% \u00b1 0.016%), (\n                    <jats:italic>Z<\/jats:italic>\n                    )\u2010\u03b2\u2010farnesene (7.07% \u00b1 0.011%), \u03b2\u2010selinene (6.81% \u00b1 0.006%), \u03b3\u2010muurolene (6.15% \u00b1 0.008%), \u03b1\u2010humulene (6.13% \u00b1 0.007%), and \u03b4\u2010cadinene (5.26% \u00b1 0.006%). Remarkably, this is the first report demonstrating the \u03b1\u2010glucosidase inhibitory activity of\n                    <jats:italic>M. officinalis<\/jats:italic>\n                    stem bark essential oil, which exhibited significant activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 188.98 \u00b1 5.60\u00a0\u00b5g\/mL), exceeding that of the standard compound acarbose (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 240.06 \u00b1 4.32\u00a0\u00b5g\/mL). In addition, the essential oil possessed cytotoxicity against MCF\u20107 and HepG2 cancer cell lines, DPPH radical scavenging, anti\u2010inflammatory activity against NO and PGE2 productions, and antimicrobial activities. Molecular docking analysis revealed that the major compounds exhibited moderate to strong binding affinities toward \u03b1\u2010glucosidase, with binding energies ranging from \u20135.6 to \u20136.9\u00a0kcal\/mol, comparable to acarbose, and predominantly stabilized by hydrophobic interactions. In addition, \u03b3\u2010muurolene and \u03b4\u2010cadinene emerged as the most promising candidates, combining strong binding affinity with optimal ADMET characteristics.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71642","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:26:27Z","timestamp":1788200787000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sesquiterpene\u2010Rich Essential Oil From\n                    <i>Magnolia officinalis<\/i>\n                    Stem Bark: Chemical Composition, Biological Activities, and In Silico Approach"],"prefix":"10.1002","volume":"23","author":[{"given":"Nguyen Thi Kim","family":"Thanh","sequence":"first","affiliation":[{"name":"Faculty of Biology University of Science Vietnam National University (VNU)  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phan Hong","family":"Minh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of Medicine and Pharmacy Vietnam National University (VNU)  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huynh Thi Ngoc","family":"Ni","sequence":"additional","affiliation":[{"name":"Faculty of Education Ha Tinh University, Cam Binh  Hatinh Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Quang","family":"Hai","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Technology Hanoi University of Industry  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le The","family":"Hoai","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Technology Hanoi University of Industry  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Ba","family":"Vinh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy Yersin University of Da Lat  Lamdong Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6922-1627","authenticated-orcid":false,"given":"Pham Minh","family":"Quan","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2948-6385","authenticated-orcid":false,"given":"Nguyen Dinh","family":"Luyen","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2413-7496","authenticated-orcid":false,"given":"Ninh The","family":"Son","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114524"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202300754"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27196441"},{"issue":"3","key":"e_1_2_9_5_1","first-page":"249","article-title":"Magnolia Genus\u2010A Systematic Review on the Composition and Biological Properties of Its Essential Oils","volume":"99","author":"Hakim Yahaya A. 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