{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:14Z","timestamp":1790546174634,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this study, the enzyme inhibition and antioxidant capacity of\n                    <jats:italic>Achillea biserrata<\/jats:italic>\n                    were determined, and their relationship with cytotoxic effects was investigated. Antiproliferative activity was evaluated by the MTT assay in L929, A549, B16F10, Hep\u20103B, PC\u20103, MCF\u20107, and CaCo\u20102 cell lines, and enzyme inhibition was assessed against tyrosinase, urease, PTP\u20101B, and DPP\u20104. Ethanol extracts showed the greatest bioactivity, whereas water extracts were the least active. The capitulum ethanol extract (CEE) exhibited the strongest inhibition of tyrosinase, urease, DPP\u20104, and PTP\u20101B (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 72.83, 40.84, 70.12, and 302.42\u00a0\u00b5g\/mL, respectively) and the highest cytotoxicity (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 168.42\u2013325.42\u00a0\u00b5g\/mL). LC\u2010MS\/MS analysis identified quinic acid as the major constituent in the stem (44.614\u00a0mg\/g extract) and capitulum (2.063\u00a0mg\/g extract), and chlorogenic acid in the leaves (45.502\u00a0mg\/g extract). Principal component analysis (PCA) integrating LC\u2010MS\/MS and bioactivity data supported the bioactive potential of\n                    <jats:italic>A. biserrata<\/jats:italic>\n                    , highlighting its promise as a pharmaceutical resource.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71643","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:26:17Z","timestamp":1788200777000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioactive Properties of\n                    <i>Achillea biserrata<\/i>\n                    M.Bieb. Extracts: Phytochemical Analysis, Antioxidant Activity, Target Enzyme Inhibition, and Cytotoxic Effects"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3405-6996","authenticated-orcid":false,"given":"Z\u00fchal Bayrak\u00e7eken","family":"G\u00fcven","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Erzincan Binali Y\u0131ld\u0131r\u0131m University  Erzincan T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4090-7227","authenticated-orcid":false,"given":"Mustafa Abdullah","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Pharmacy Dicle University  Diyarbakir T\u00fcrkiye"},{"name":"Dicle University Science and Technology Application and Research Center (DUBTAM)  Diyarbakir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1344-8747","authenticated-orcid":false,"given":"Huseyin","family":"Inceer","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Science Karadeniz Technical University  Trabzon T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010021\u201000514\u2010z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573408019666230731113105"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/20503121211034366"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21674"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2024.149785"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2023.188968"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2014.99"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/gastroent12020011"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/diseases9040066"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1339750"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2024.102626"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25137033"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867331666230914103645"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137027"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00376"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13143588"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.2454"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_862_16"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13070796"},{"issue":"3","key":"e_1_2_8_21_1","first-page":"173","article-title":"A Review on Phytochemistry and Medicinal Properties of the Genus Achillea","volume":"19","author":"Saeidnia S.","year":"2011","journal-title":"DARU: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences"},{"issue":"5","key":"e_1_2_8_22_1","first-page":"530","article-title":"Experimental and Clinical Studies on Pharmacological Actions of the Genus Achillea: A Comprehensive and Updated Review","volume":"14","author":"Saadat S.","year":"2024","journal-title":"Avicenna Journal of Phytomedicine"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/applmicrobiol2010016"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants11030447"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants13071043"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.12991\/jrp.2019.164"},{"key":"e_1_2_8_27_1","unstructured":"F.Ayaz S.Hay\u0131rl\u0131oglu\u2010Ayaz andH.Inceer (2003) Total phenols and condensed tannins in the leaves of some Anthemideae species from Northeast Anatolia."},{"issue":"4","key":"e_1_2_8_28_1","first-page":"3193","article-title":"Essential Oil Composition and Antimicrobial Activities of Achillea Biserrata M. 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