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This study investigated the association of aqueous extract of\n                    <jats:italic>Mitracarpus frigidus<\/jats:italic>\n                    aerial parts (MFAq) and hydroalcoholic extract of\n                    <jats:italic>Lantana camara<\/jats:italic>\n                    leaves (LCHA) incorporated into chitosan\u2010based films for potential dermatological applications. Different extract ratios were initially evaluated for phytochemical composition, cytotoxicity, antioxidant, and anti\u2010inflammatory activities. The 1:1 MFAq:LCHA association was selected based on its balanced phytochemical profile, low cytotoxicity, and significant biological activity, with eleven major compounds identified by UFLC\u2010QTOF\u2010MS. This association reduced nitric oxide production by 88.83% and lipid droplet accumulation by 59.48%, while showing pronounced antioxidant activity. Chitosan films containing 0.5%, 1.0%, and 2.5% (w\/w) of the selected association were homogeneous, thermally stable, and exhibited suitable mechanical and physicochemical properties for topical application. The films maintained high cell viability and demonstrated significant antioxidant, anti\u2010inflammatory, and wound\u2010healing activities, including reductions in nitric oxide (up to 59.58%), reactive oxygen species, and pro\u2010inflammatory cytokines (up to 40.57% and 62.27% for IL\u20106 and IL\u201012), as well as enhanced fibroblast migration. Overall, these findings indicate that MFAq:LCHA\u2010loaded chitosan films represent a promising biodegradable and multifunctional platform for the treatment of skin disorders associated with inflammation and oxidative stress. Further in vivo studies are warranted to confirm their therapeutic efficacy and safety.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71645","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:52:11Z","timestamp":1790830331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic Phytochemicals From\n                    <i>Mitracarpus frigidus<\/i>\n                    (Willd. ex Roem. &amp; Schult.) K. Schum. and\n                    <i>Lantana camara<\/i>\n                    Linn. in Chitosan Biofilms: Antioxidant and Anti\u2010Inflammatory Activities With Wound\u2010Healing Potential"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2410-1802","authenticated-orcid":false,"given":"Natasha Silva","family":"Mayrink","sequence":"first","affiliation":[{"name":"Department of Biochemistry Laboratory of Bioactive Natural Products Institute of Biological Sciences Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Bertolini","family":"Fajardo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Laboratory of Bioactive Natural Products Institute of Biological Sciences Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariane Rocha 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Lima","family":"Paula","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Laboratory of Bioactive Natural Products Institute of Biological Sciences Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara Melo","family":"Campos","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Laboratory of Bioactive Natural Products Institute of Biological Sciences Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Clara Machado Resende","family":"Guedes","sequence":"additional","affiliation":[{"name":"Department of Parasitology Microbiology and Immunology Institute of Biological Sciences Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Fernando","family":"Cappa de 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