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Male mice were daily administered rotenone (3\u00a0mg\/kg, i.p.) 1\u00a0h after being treated with WSMoL (1, 2, or 4\u00a0mg\/kg, i.p.), levodopa (L\u2010DOPA, 10\u00a0mg\/kg), or vehicle for 10 days. To assess dopaminergic involvement, another group received the D1 receptor antagonist SCH\u201023390 co\u2010administered with WSMoL (4\u00a0mg\/kg). The healthy control group received vehicle only. Motor performance was evaluated using the rotarod, cylinder, and open field tests. Brain levels of monoamines and cytokines as well as redox status were measured. WSMoL prevented the rotenone\u2010related deficits in motor performance, which was accompanied by non\u2010depleted dopamine and serotonin levels. WSMoL also mitigated the increase of IL\u20106, IL\u201017A, IFN\u2010\u03b3, and TNF\u2010\u03b1. In addition, it prevented oxidative stress by avoiding the exacerbation of superoxide production, lipid peroxidation, and NADPH oxidase activity, while maintaining catalase, superoxide dismutase (SOD), and reduced glutathione (GSH) levels. The data show that D1 receptor\u2010mediated signaling contributes to WSMoL effects. In conclusion, WSMoL attenuates motor deficits and neuroinflammation in a PD model, which supports its potential as a neuroprotective agent and warrants further mechanistic and translational studies.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71646","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:46:56Z","timestamp":1788202016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Moringa oleifera<\/i>\n                    Lam. Seed Lectin (WSMoL) Attenuates Parkinsonian Symptoms in Mice via Anti\u2010Inflammatory, Antioxidant, and Neurotransmitter\u2010Modulating Effects"],"prefix":"10.1002","volume":"23","author":[{"given":"Leydianne Leite de Siqueira","family":"Patriota","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias Universidade Federal de Pernambuco Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuel Davi Lima de Matos","family":"Le\u00e3o","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias Universidade Federal de Pernambuco Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria N\u00edvea Bezerra","family":"da Silva","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias Universidade Federal de Pernambuco Recife 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