{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:12Z","timestamp":1790546172260,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Atriplex halimus<\/jats:italic>\n                    L. is a Mediterranean halophyte traditionally used in Moroccan ethnomedicine. The present study aimed to characterize the phytochemical profile of its aqueous (EA) and hydroethanolic (EHA) extracts and to provide a preliminary evaluation of their antibacterial and cytotoxic properties, supported by exploratory in silico analyses.\n                    <jats:italic>UHPLC\u2010MS\/MS<\/jats:italic>\n                    profiling identified 17 compounds in EA and 20 in EHA, with\n                    <jats:italic>trans<\/jats:italic>\n                    \u2010cinnamic acid as the most abundant constituent (73.73\u00a0\u00b5g\/g in EA and 84.02\u00a0\u00b5g\/g in EHA), together with catechin, epigallocatechin, and six vitamins, vitamin C being the most abundant. Agar\u2010diffusion and well\u2010diffusion assays showed that both extracts inhibited\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ,\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    , and\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    , with minimum inhibitory concentrations ranging from 10 to 30\u00a0mg\/mL indicating a modest antibacterial activity. In the brine shrimp lethality assay on\n                    <jats:italic>Artemia salina<\/jats:italic>\n                    , used here as a preliminary cytotoxicity screen rather than an indicator of anticancer activity, both extracts displayed dose\u2010dependent lethality. Exploratory molecular docking against DNA gyrase and enoyl\u2010acyl carrier protein reductase suggested that catechin and epigallocatechin could potentially interact with these bacterial targets. Overall, the present findings support\n                    <jats:italic>A. halimus<\/jats:italic>\n                    as a chemically rich source of polyphenols and vitamins that warrants further mechanistic and pharmacological investigation, without supporting any direct therapeutic claim.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71647","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:31:42Z","timestamp":1788201102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Silico and In Vitro Evaluation of\n                    <i>Atriplex halimus<\/i>\n                    : Antibacterial Activity, Molecular Docking, ADMET Profiling, and Cytotoxicity Assessment"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1446-600X","authenticated-orcid":false,"given":"Mohammed","family":"Roubi","sequence":"first","affiliation":[{"name":"Laboratory of Bioresources Biotechnology Ethnopharmacology and Health Faculty of Sciences Mohammed First University  Oujda Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4399-1695","authenticated-orcid":false,"given":"Ayoub","family":"Farihi","sequence":"additional","affiliation":[{"name":"Laboratory of Bioresources Biotechnology Ethnopharmacology and Health Faculty of Sciences Mohammed First University  Oujda Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0722-7414","authenticated-orcid":false,"given":"Mohammed","family":"Dalli","sequence":"additional","affiliation":[{"name":"Higher Institute of Nursing Professions and Health Techniques  Oujda 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